Results 31 to 40 of about 681,576 (264)
Middle Ear Administration of a Particulate Chitosan Gel in an in vivo Model of Cisplatin Ototoxicity
Frontiers in Cellular Neuroscience, 2019 Background Middle ear (intratympanic, IT) administration is a promising therapeutic method as it offers the possibility of achieving high inner ear drug concentrations with low systemic levels, thus minimizing the risk of systemic side effects and drug ...
Pernilla Videhult Pierre +7 more
semanticscholar +1 more source
USP14 inhibition corrects an in vivo model of impaired mitophagy
EMBO Molecular Medicine, 2018 Mitochondrial autophagy or mitophagy is a key process that allows selective sequestration and degradation of dysfunctional mitochondria to prevent excessive reactive oxygen species, and activation of cell death.
J. Chakraborty +9 more
semanticscholar +1 more source
Bioengineering, 2023 Alveolar cleft is a common congenital deformity that requires surgical intervention, notably using autologous bone grafts in young children. Bone substitutes, in combination with mesenchymal stem cells (MSCs), have shown promise in the repair of these ...
Alban Destrez +5 more
doaj +1 more source
Frontiers in Medicine, 2019 Tumor budding (TB) is an important prognostic parameter in colorectal cancer (CRC) and associated with metastasis. However, the mechanisms of TB have not been fully elucidated and a major limitation is the absence of in vivo models.
Laurent M. C. Georges +6 more
semanticscholar +1 more source
Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
doaj +1 more source
Optimization of a closed rat tibial fracture model
Journal of Experimental Orthopaedics, 2018 Background The use of a closed fracture model has become the preferred model to study the fracture healing process, given that the periosteum and the soft tissue surrounding the fracture site play an important role in the fracture healing process.
Kareem Obayes Handool +6 more
doaj +1 more source
Animal Models in Human Adenovirus Research
Biology, 2021 Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals.
Luca D. Bertzbach +2 more
doaj +1 more source
Highly Diluted Acetylcholine Promotes Wound Repair in an In Vivo Model
Advances in wound care, 2018 Objective: Wound healing is a dynamic, interactive, and complex process that involves a series of events, including inflammation, migration, proliferation, granulation tissue formation, and matrix remodeling.
F. Uberti +7 more
semanticscholar +1 more source
Safety and biodegradability of a synthetic dural sealant patch (Liqoseal) in a porcine cranial model
Animal Models and Experimental Medicine, 2021 Background Liqoseal consists of a watertight layer of poly(ester)ether urethane and an adhesive layer containing polyethylene glycol‐N‐hydroxysuccinimide (PEG‐NHS).
Ahmet Kinaci +5 more
doaj +1 more source
Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish Larvae
Brain Sciences, 2022 Brain tumours are the most common cause of death among children with solid tumours, and high-grade gliomas (HGG) are among the most devastating forms with very poor outcomes. In the search for more effective treatments for paediatric HGG, there is a need
Susanna Larsson +2 more
doaj +1 more source