Results 11 to 20 of about 2,991,035 (302)
Modeling metastasis in vivo [PDF]
Carcinogenesis, 2004 Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis.
Chand, Khanna, Kent, Hunter
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In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus
International Journal of Molecular Sciences, 2022 Pemphigus is a life-threatening autoimmune disease. Several phenotypic variants are part of this family of bullous disorders. The disease is mainly mediated by pathogenic autoantibodies, but is also directed against two desmosomal adhesion proteins, desmoglein 1 (DSG1) and 3 (DSG3), which are expressed in the skin and mucosae.
Roberta Lotti +4 more
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Optimisation of the Chicken Chorioallantoic Membrane Assay in Uveal Melanoma Research
Pharmaceutics, 2021 The treatment of uveal melanoma and its metastases has not evolved sufficiently over the last decades in comparison to other tumour entities, posing a great challenge in the field of ocular oncology.
Ekaterina A. Sokolenko +8 more
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Advancements in the Alcohol-Associated Liver Disease Model
Biomolecules, 2022 Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad spectrum of liver damage. The presentation of ALD can include simple steatosis, steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC ...
Lin Zhu +7 more
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In vivo cerebral aneurysm models [PDF]
Neurosurgical Focus, 2019 Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage and is associated with significant morbidity and death. Up to 50% of individuals do not survive aneurysm rupture, with the majority of survivors suffering some degree of neurological deficit.
John W, Thompson +9 more
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Frontiers in Cellular and Infection Microbiology, 2021 The larvae of the insect Galleria mellonella, have recently been established as a non-mammalian infection model for the Mycobacterium tuberculosis complex (MTBC).
Masanori Asai +7 more
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In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and LimitationsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver
Young-Sun Lee, Ekihiro Seki
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SERINC5 Potently Restricts Retrovirus Infection
mBio, 2020 The serine incorporator (SERINC) proteins are multipass transmembrane proteins that affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were recently shown to possess antiretroviral activity for a number of retroviruses ...
Uddhav Timilsina +4 more
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Model of host-pathogen Interaction dynamics links In vivo optical imaging and immune responses [PDF]
, 2016 Tracking disease progression in vivo is essential for the development of treatments against bacterial infection. Optical imaging has become a central tool for in vivo tracking of bacterial population development and therapeutic response.
Ale, A +7 more
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A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]
, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro +6 more
core +3 more sources