Results 11 to 20 of about 681,576 (264)
In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus
International Journal of Molecular Sciences, 2022 Pemphigus is a life-threatening autoimmune disease. Several phenotypic variants are part of this family of bullous disorders. The disease is mainly mediated by pathogenic autoantibodies, but is also directed against two desmosomal adhesion proteins, desmoglein 1 (DSG1) and 3 (DSG3), which are expressed in the skin and mucosae.
Roberta Lotti +4 more
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Modeling metastasis in vivo [PDF]
Carcinogenesis, 2004 Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis.
Chand, Khanna, Kent, Hunter
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In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and LimitationsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver
Young-Sun Lee, Ekihiro Seki
doaj +1 more source
Murine SEC24D can substitute functionally for SEC24C during embryonic development
Scientific Reports, 2021 The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes encode four Sec24 paralogs (Sec24a-d), with two subfamilies based on sequence homology ...
Elizabeth J. Adams +12 more
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Re-epithelialization and immune cell behaviour in an ex vivo human skin model
Scientific Reports, 2020 A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification.
A. Rakita +4 more
semanticscholar +1 more source
Generation of human tonsil epithelial organoids as an ex vivo model for SARS-CoV-2 infection
Biomaterials, 2022 The palatine tonsils (hereinafter referred to as “tonsils”) serve as a reservoir for viral infections and play roles in the immune system's first line of defense.
Han Kyung Kim +15 more
semanticscholar +1 more source
Pharmaceutics, 2021 The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route.
Ruiying Li +5 more
doaj +1 more source
In vivo cerebral aneurysm models [PDF]
Neurosurgical Focus, 2019 Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage and is associated with significant morbidity and death. Up to 50% of individuals do not survive aneurysm rupture, with the majority of survivors suffering some degree of neurological deficit.
John W, Thompson +9 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 In this study, we describe a nano-carrier system for propolis that is able to cross an in vitro model of the blood-brain barrier (BBB) and effectively reduce the virulence of Cryptococcus neoformans in animal models.
Patcharin Thammasit +11 more
doaj +1 more source
Frontiers in Microbiology, 2020 The aim of this study was to evaluate the effect of a moxifloxacin-loaded organic-inorganic sol-gel with different antibiotic concentration in the in vitro biofilm development and treatment against Staphylococcus aureus, S.
J. Aguilera-Correa +7 more
semanticscholar +1 more source