Results 11 to 20 of about 1,733,123 (312)
Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies
Eye and Brain, 2010 Julio C Rojas, Francisco Gonzalez-LimaDepartments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, USAAbstract: This review summarizes the characteristics of a rodent toxicologic model of optic neuropathy induced by ...
Julio C Rojas, Francisco Gonzalez-Lima
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In Vitro, Ex Vivo, and In Vivo Models for the Study of Pemphigus
International Journal of Molecular Sciences, 2022 Pemphigus is a life-threatening autoimmune disease. Several phenotypic variants are part of this family of bullous disorders. The disease is mainly mediated by pathogenic autoantibodies, but is also directed against two desmosomal adhesion proteins, desmoglein 1 (DSG1) and 3 (DSG3), which are expressed in the skin and mucosae.
Roberta Lotti +4 more
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Modeling metastasis in vivo [PDF]
Carcinogenesis, 2004 Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis.
Chand, Khanna, Kent, Hunter
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In vivo cerebral aneurysm models [PDF]
Neurosurgical Focus, 2019 Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage and is associated with significant morbidity and death. Up to 50% of individuals do not survive aneurysm rupture, with the majority of survivors suffering some degree of neurological deficit.
John W, Thompson +9 more
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Optimisation of the Chicken Chorioallantoic Membrane Assay in Uveal Melanoma Research
Pharmaceutics, 2021 The treatment of uveal melanoma and its metastases has not evolved sufficiently over the last decades in comparison to other tumour entities, posing a great challenge in the field of ocular oncology.
Ekaterina A. Sokolenko +8 more
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Advancements in the Alcohol-Associated Liver Disease Model
Biomolecules, 2022 Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad spectrum of liver damage. The presentation of ALD can include simple steatosis, steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC ...
Lin Zhu +7 more
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In vivo models of angiogenesis [PDF]
Journal of Cellular and Molecular Medicine, 2006 The process of building new blood vessels (angiogenesis) and controlling the propagation of blood vessels (anti-angiogenesis) are fundamental to human health, as they play key roles in wound healing and tissue growth. More than 500 million people may stand to benefit from anti- or pro-angiogenic treatments in the coming decades [National Cancer ...
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The Spread of Antibiotic Resistance Genes In Vivo Model
, 2022 Infections caused by antibiotic-resistant bacteria are a major public health threat. The emergence and spread of antibiotic resistance genes (ARGs) in the environment or clinical setting pose a serious threat to human and animal health worldwide ...
Huimin Chen +9 more
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In Vivo Facilitated Diffusion Model
PLoS ONE, 2013 Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed.
Bauer, Maximilian +1 more
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In Vitro and In Vivo Models to Study the Zoonotic Mosquito-Borne Usutu Virus
Viruses, 2020 Usutu virus (USUV), a mosquito-borne zoonotic flavivirus discovered in South Africa in 1959, has spread to many European countries over the last 20 years.
Emna Benzarti, Mutien Garigliany
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