Results 111 to 120 of about 1,321,319 (311)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
A Statistical Model for In Vivo Neuronal Dynamics
PLOS ONE, 2015 Cortical neurons are constantly active. Even in the absence of an explicit stimulus, cortical neurons are spontaneously active and display large fluctuations of their membrane potentials. The increasing amount of intracellular recordings of spontaneous activity as well as the increasing number of theories which critically rely on a characterization of ...
Surace Simone Carlo, Pfister Jean-Pascal
openaire +9 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Using In Vivo Models to Understand Melanogenesis [PDF]
, 2020 The diversity of hair and skin color is a direct result of melanin synthesis occurring in melanocytes. Melanogenesis is a set of highly regulated processes that occur in a specialized organelle called the melanosome.
Flesher, Jessica Leigh
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2006 Implant infections due to staphylococci are one of the greatest threats facing patients receiving implant devices. For many years researchers have sought to understand the mechanisms involved in the adherence of the bacterium to the implanted device and
M. Herrmann +5 more
core +2 more sources
Fluorescent in vivo models for hematopoietic stem cell and lymphoid lineage analysis
, 2022 For many years, hematopoietic stem cell kinetics and/or cell signaling pathway activity has been studied through fluorescent in vitro or in vivo models.
Roo J.J.D. de
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Pre- and post-copulatory traits are affected by experimental inbreeding, but they are not correlated
BMC BiologyBackground It has been suggested that the expression of males’ secondary sexual traits provides reliable indicators of their sperm traits, predicting positive correlations between pre- and post-copulatory traits (Fertility Indicator Hypothesis).
Doris Nicolakis +4 more
doaj +1 more source