Results 101 to 110 of about 1,321,319 (311)

In Vitro and In Vivo Models of Spinal Muscular Atrophy

, 2017
Spinal muscular Atrophy (SMA) is caused by reduced levels of the SMN protein. In humans this is caused by loss of SMN1 and retention of SMN2. The challenge in modelling SMA, in either tissue culture cells or animals, is first to obtain the desired SMN ...
Arthur H. M. Burghes, W. David Arnold
core   +1 more source

Oxidative Stress Monitoring in In Vitro and In Vivo Models

, 2020
In aerobic organisms, cellular respiration is an essential process that is divided into several steps. The third and last step is called oxidative phosphorylation, which occurs in the mitochondria, specifically in the inner mitochondrial membrane.
Lilian Cristina Pereira, Sales, Bianca Camargo Penteado [UNESP], Thania Rios Rossi Lima, Bianca Camargo Penteado Sales, Lima, Thania Rios Rossi [UNESP], Pereira, Lilian Cristina [UNESP]   +5 more
core   +1 more source

Endothelial dysfunction of bypass graft: direct comparison of in vitro and in vivo models of ischemia-reperfusion injury [PDF]

, 2015
BACKGROUND: Although, ischemia/reperfusion induced vascular dysfunction has been widely described, no comparative study of in vivo- and in vitro-models exist.
Klein Stephanie, Klein S, Korkmaz S, Szabó, Gábor Balázs, Veres, Gábor, Radovits, Tamás, Hegedűs Péter, Hegedűs, Péter, Veres Gábor, Karck Matthias, Szabó Gábor, Zöller Raphael, Korkmaz Sevil, Schmidt Harald, Schmidt H, Barnucz, Enikő, Radovits Tamás, Szabó, Gábor, Barnucz Enikő, Zoller R, Karck M   +20 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Abstract 3225: Cellular and in vivo models for the analyses of B-Raf and c-Src inhibitors

, 2010
Cytosolic kinases c-Src and B-Raf represent proto-oncogenes of which mutant or overexpressed variants have been shown to cause cancer. Efforts are taken to develop inhibitors specifically addressing these kinases, some of which have already been approved
Jan E. Ehlert, Bettina Mutschler, Michael HG Kubbutat, Melanie Müller, Andreas Lingnau, Steffen Hoffmann   +5 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Are In Vitro Human Blood–Brain–Tumor-Barriers Suitable Replacements for In Vivo Models of Brain Permeability for Novel Therapeutics?

, 2021
Background: High grade gliomas (HGG) are incapacitating and prematurely fatal diseases. To overcome the poor prognosis, novel therapies must overcome the selective and restricted permeability of the blood–brain barrier (BBB).
Viive M. Howell, Georges E. Grau, Heather Donaghy, Archana Prashanth, Connie I. Diakos, Shihani P. Stoner, Kelly J. McKelvey, Amanda L. Hudson, Helen R. Wheeler   +8 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Ex Vivo and In Vivo Models for Endoscopic Submucosal Dissection Training

, 2012
Endoscopic submucosal dissection is a technically challenging but highly effective technique for the treatment of well selected early neoplasms in the digestive tract. Although it is frequently performed in East Asian countries, the Western world has not
Parra-Blanco, A., Gonzalez, N., Arnau, M. R.   +2 more
core   +1 more source