Results 161 to 170 of about 1,311,826 (266)

Neuropharmacological Validation of <i>Clinopodium pulchellum</i> (Panizara): Unveiling the Anxiolytic and Antidepressant Mechanism via In Vivo Models and Molecular Docking. [PDF]

Plants (Basel)
Valdiviezo-Campos JE, Fiestas-Jacinto R, Olascuaga-Castillo KA, Ruiz-Reyes SG, Rubio-Guevara SR, Rengifo-Penadillos RA, Siguas-Peña JF.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Calcification Potential of Intraocular Lenses (IOL). Predictive in vitro and in vivo models. [PDF]

J Mater Sci Mater Med
Gray B, Koutsoukos P, Huang LC.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Impact of contact parameters on lesion dimensions during circular Pulsed-Field ablation in ex vivo and in vivo models. [PDF]

Sci Rep
Hu X, Li W, Ren B, Li F, Gong A, Zhu X, Xie L, Cao Y, Li Z, Zeng R.   +9 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

10H-phenothiazine exerts beneficial effects in spinal muscular atrophy in vitro and in vivo models. [PDF]

Sci Rep
Rasà DM, Stanga S, Santonicola P, Mazzarella N, Camera A, Matino I, Zampi G, Boido M, Di Schiavi E, Vercelli A.   +9 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Aqueous extract of Psidium glaziovianum Kiaersk leaves acts on muscarinic and opioid receptors and reduces cytokines and inflammatory infiltrates in vivo models. [PDF]

Inflammopharmacology
Costa WK, Fernandes PHE, da Silva PM, de Freitas SJO, Camêlo EA, Nunes GGI, Barbosa Machado JC, Ferreira MRA, Soares LAL, de Oliveirad AM, da Silva MV, Dos Santos Correia MT.   +11 more
europepmc   +1 more source