Results 191 to 200 of about 1,311,826 (266)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

In Vitro and In Vivo Models for Drug Development Against Two Hemorrhagic <i>Hareavirales</i>: Rift Valley Fever and Crimean Congo Hemorrhagic Fever Viruses. [PDF]

Viruses
Chaput S, Nougairède A, Touret F.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Retraction of: VEGF as a Survival Factor in Ex Vivo Models of Early Diabetic Retinopathy. [PDF]

Invest Ophthalmol Vis Sci
europepmc   +1 more source

Effects of L-Arginine on Bone Metabolism: Evidence from In Vitro and In Vivo Models. [PDF]

Int J Mol Sci
Pertusa C, Carrasco-García Á, Aliaga R, Suay L, Alonso-Iglesias E, Cano A, Tarín JJ, García-Pérez MÁ.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Preclinical ex vivo and in vivo models to study immunotherapy agents and their combinations as predictive tools toward the clinic. [PDF]

J Immunother Cancer
Eguren-Santamaria I, Melero I, Rodríguez I, Ortego I, Armero M, Galvez-Cancino F, López-Janeiro A, De Andrea CE, Sanmamed MF.   +8 more
europepmc   +1 more source

In vivo model of hepatocarcinogenesis

Exytablishment of, and report on the experimental results of the in vivo model of hepatocarcinogenesis.
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Gut-on-a-chip platforms: Bridging in vitro and in vivo models for advanced gastrointestinal research. [PDF]

Physiol Rep
Ofori-Kwafo A, Sigdel I, Al Mamun E, Zubcevic J, Tang Y.   +4 more
europepmc   +1 more source