Results 71 to 80 of about 38,166 (233)

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

The Fight against Poliovirus Is Not Over

Microorganisms, 2023
Poliovirus (PV), the virus that causes both acute poliomyelitis and post-polio syndrome, is classified within the Enterovirus C species, and there are three wild PV serotypes: WPV1, WPV2 and WPV3.
Chaldam Jespère Mbani, Magloire Pandoua Nekoua, Donatien Moukassa, Didier Hober   +3 more
doaj   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Will containment of wild poliovirus in laboratories and inactivated poliovirus vaccine production sites be effective for global certification?

Bulletin of the World Health Organization
The absolute laboratory containment of any virus cannot be guaranteed, but a wealth of experience indicates that effective containment of wild poliovirus materials for global certification is technically and operationally feasible.
Walter R. Dowdle, Christopher Wolff, Raymond Sanders, Scott Lambert, Maureen Best   +4 more
doaj   +1 more source

Immunogenicity of intramuscular fractional dose of inactivated poliovirus vaccine.

Journal of Infectious Diseases, 2019
INTRODUCTION Intradermal (id) fractional Inactivated Poliovirus Vaccine (fIPV, 1/5th of normal IPV dose) is safe and immunogenic, however, id administration is perceived as difficult. We compared fIPV immunogenicity administered id or intramuscularly (im)
S. Resik, O. Mach, Alina Tejeda, V. Jeyaseelan, Magile C Fonseca, M. Díaz, Nilda Alemañy, Lai Heng Hung, Y. Alemán, Ileana Mesa, Gloria García, R. Sutter   +11 more
semanticscholar   +1 more source

Systematic Review of Postvaccination Ocular Adverse Events: A Comprehensive Analysis of Published Reports

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Ocular adverse events following COVID‐19 vaccination are well described; however, systematic analyses of non‐COVID antiviral vaccines remain limited. This review aimed to evaluate ocular complications associated with non‐COVID antiviral immunizations, including influenza, varicella‐zoster (VZV), human papillomavirus (HPV), and hepatitis B (HBV)
Yaru Zou, Koju Kamoi, Yuan Zong, Jing Zhang, Mingming Yang, Kyoko Ohno‐Matsui   +5 more
wiley   +1 more source

A Pseudovirus‐Based Method for the Simultaneous Quantitation of Neutralization Antibodies Against All Three Poliovirus Serotypes

MedComm, Volume 6, Issue 12, December 2025.
By optimizing P1 expression, sensitive cell selection, and plasmid transfection ratios, we produced a high‐titer poliovirus pseudovirus. Based on high‐titer pseudovirus encoding distinct fluorophores (E2, eGFP, and RFP), we developed a tri‐color pseudovirus‐based neutralization assay (PBNA) for the simultaneous quantification of neutralizing antibodies
Meiyan Liu, Yuanling Yu, Yadong Li, Zexin Tao, Lan Huang, Xi Wu, Yong Zhang, Shuangli Zhu, Qiang Sun, Tianjiao Ji, Dongyan Wang, Ziteng Liang, Shuo Liu, Meina Cai, Yimeng An, Jierui Li, Weijin Huang, Guoyang Liao, Li Yi, Lei Ma, Li Zhang, Youchun Wang   +21 more
wiley   +1 more source

Viral Aetiology of Acute Flaccid Paralysis Surveillance Cases, before and after Vaccine Policy Change from Oral Polio Vaccine to Inactivated Polio Vaccine

Journal of Tropical Medicine, 2014
Since 1992, surveillance for acute flaccid paralysis (AFP) cases was introduced in Malaysia along with the establishment of the National Poliovirus Laboratory at the Institute for Medical Research.
T. S. Saraswathy Subramaniam, Mohd Apandi Apandi, Rohani Jahis, Mohd Samsul Samsudin, Zainah Saat   +4 more
doaj   +1 more source

Recommendation for use of diphtheria and tetanus toxoids and acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate, and hepatitis B vaccine in infants

Clinical and experimental pediatrics, 2021
In April 2020, the Ministry of Food and Drug Safety licensed a hexavalent combined diphtheria and tetanus toxoids and acellular pertussis (DTaP), inactivated poliovirus (IPV), Haemophilus influenzae type b (Hib) conjugated to tetanus protein, and ...
H. Cho, Su Eun Park, Y. Kim, D. Jo, Y. Kim, B. Eun, T. Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, E. Cho, Jong Gyun Ahn, E. Choi   +12 more
semanticscholar   +1 more source

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer‐associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor‐associated macrophages, T cells, neutrophils, and NK cells in a positive‐feedback loop to sculpt tumor immune microenvironment and participate in tumor activities and antitumor therapy ...
Ya Li, Xingpeng Di, Jiawei Chen, Jingwen Wei, Tianyue Li, Kunjie Wang, Banghua Liao, Deyi Luo   +7 more
wiley   +1 more source