Results 51 to 60 of about 156,029 (310)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Epizootiological investigation of equine herpesvirus type 1 infection among Japanese racehorses before and after the replacement of an inactivated vaccine with a modified live vaccine

BMC Veterinary Research, 2019
Background Equine herpesvirus type 1 (EHV-1) infection is a major cause of pyrexias in winter among Japanese racehorses. In 2014–2015, the Japan Racing Association (JRA) changed the EHV-1 vaccine from an inactivated vaccine to a live vaccine (both ...
Hiroshi Bannai, Koji Tsujimura, Manabu Nemoto, Minoru Ohta, Takashi Yamanaka, Hiroshi Kokado, Tomio Matsumura   +6 more
doaj   +1 more source

Study of the Effects of Several SARS-CoV-2 Structural Proteins on Antiviral Immunity

Vaccines, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike (S) protein is a critical viral antigenic protein that enables the production of neutralizing antibodies, while other structural proteins, including the membrane (M), nucleocapsid (N)
Rong Yue, Fengyuan Zeng, Danjing Ma, Ziyan Meng, Xinghang Li, Zhenxiao Zhang, Haobo Zhang, Qi Li, Langxi Xu, Zhenye Niu, Dandan Li, Yun Liao, Guorun Jiang, Li Yu, Heng Zhao, Ying Zhang, Longding Liu, Qihan Li   +17 more
doaj   +1 more source

Pengaruh Dosis Vaksin Newcastle Disease Inaktif Pada Itik Betina Terhadap Jumlah Sel Darah Putih Dan Titer Antibodi [PDF]

, 2016
This study are determines to: 1) the effect of ND vaccine dose to the number of white blood cells produced in the female ducks; 2) the effect of ND vaccine doses to the amount of antibody titers produced in the female ducks.
Pratama, L. (Luthfi), Santosa, P. E. (Purnama), Siswanto, S. (Siswanto)   +2 more
core  

The comparative value of feline virology research: can findings from the feline lentiviral vaccine be translated to humans? [PDF]

, 2017
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV).
Beczkowski, Paweł M., Harris, Matthes, Hosie, Margaret J., Logan, Nicola, Techakriengkrai, Navapon, Willett, Brian   +5 more
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Improved Immunogenicity of the Inactivated F Genotype Mumps Vaccine against Diverse Circulating Mumps Viruses in Mice

Vaccines, 2023
Mumps is an acute infectious disease caused by the mumps virus (MuV). Despite high global vaccination coverage, mumps outbreaks continue to occur, even in vaccinated populations.
Hyeran Won, Ah-Ra Kim, Gyung Tae Chung, Su Hwan Kim, Jung-Sik Yoo, June-Woo Lee   +5 more
doaj   +1 more source

The post-2009 influenza pandemic era : time to revisit antibody immunodominance [PDF]

, 2018
The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift ...
Caton, Khurana, Krammer, Krause, Kristien Van Reeth, Liu, Van Reeth   +6 more
core   +1 more source

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, EarlyView.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Inactivated smallpox vaccine. A comparison of inactivation methods [PDF]

Journal of Hygiene, 1970
Vaccines were prepared from a single pool of high-titred vaccinia virus and inactivated by six methods, namely heat, formalin, hydroxylamine, β-propiolactone, ultraviolet irradiation, and visible light and methylene blue. Large doses of the vaccines were required to protect mice against intracerebral challenge.
G S, Turner, E J, Squires, H G, Murray
openaire   +2 more sources