Results 241 to 250 of about 131,634 (310)

Revisiting the Association of ABO Blood Groups Alongside Vaccination With Patient Outcomes in SARS‐CoV‐2 Respiratory Infection: A Prospective Observational Cohort Study in Bristol, UK 2020–2023

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Background The 2023 SARS‐CoV‐2 environment differs greatly from the initial outbreak, with new variants and widespread vaccination. Early in the pandemic, blood group A was linked to increased hospitalisation and poor outcomes, but its role now, since the availability of vaccination, is unclear.
Alice Hathaway, George Qian, Jade King, Serena McGuinness, Nick Maskell, Jennifer Oliver, Adam Finn, Leon Danon, Robert Challen, Ashley M. Toye, Catherine Hyams, The Avon CAP Research Group, Amelia Langdon, Amy Taylor, Anabella Turner, Anya Mattocks, Bethany Osborne, Charli Grimes, Claire Mitchell, David Adegbite, Emma Bridgeman, Emma Scott, Fiona Perkins, Francesca Bayley, Gabriella Ruffino, Gabriella Valentine, Grace Tilzey, Jane Kinney, Johanna Kellett Wright, Julia Brzezinska, Julie Cloake, Katarina Milutinovic, Kate Helliker, Katie Maughan, Kazminder Fox, Konstantina Minou, Lana Ward, Leah Fleming, Leigh Morrison, Lily Smart, Louise Wright, Lucy Grimwood, Maddalena Bellavia, Madeleine Clout, Marianne Vasquez, Milo Jeenes‐Flanagan, Natalie Chang, Niall Grace, Maria Garcia Gonzalez, Nicola Manning, Oliver Griffiths, Pip Croxford, Peter Sequenza, Rajeka Lazarus, Rhian Walters, Robin Marlow, Robyn Heath, Rupert Antico, Sandi Nammuni Arachchge, Seevakumar Suppiah, Taslima Mona, Tawassal Riaz, Vicki Mackay, Zandile Maseko, Zoe Taylor, Zsuzsa Szasz‐Benczur, Zsolt Friedrich   +66 more
wiley   +1 more source

An HBV‐Derived Peptide Poly6 as a Novel Candidate for Functional Cure Via IFN‐I–Mediated Epigenetic Regulation of cccDNA

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Covalently closed circular DNA (cccDNA) represents the central obstacle to achieving a functional cure for chronic hepatitis B virus (HBV) infection. Poly6, a peptide encoded within the HBV genome, was investigated for antiviral efficacy in hepatocyte‐derived cell lines, hydrodynamic injection models, and HBV transgenic mice.
Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Yu‐Min Choi, Bum‐Joon Kim   +5 more
wiley   +1 more source

IgA Antibodies Reveal Covert Infection With Mpox Virus in People Living With HIV in the Community: A Prospective Longitudinal Cohort Survey

MedComm, Volume 7, Issue 4, April 2026.
This study identified covert infection of MPXV among people living with HIV and MPXV‐IgA was the effective indicator. The combined use of two antigen protein set of MPXV (B6R plus E8L and E8L plus H3L) yield IgA test results comparable to those obtained with the MPXV.
Rui Song, Danyang Li, Lan Chen, Xiao Wang, Qiao Zhang, Zhixia Gu, Xueqi Chi, Yuanyuan Zhang, Jing Han, Li Guo, Ronghua Jin, Lili Ren, Jianwei Wang   +12 more
wiley   +1 more source

Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei, Xuxu Xu, Jing Bao, Zhenjiang Pan   +3 more
wiley   +1 more source

DNAzyme‐Based Nanostructures for Dynamic Cell Regulation and Sensing

ChemistryOpen, Volume 15, Issue 4, April 2026.
This review explores DNAzyme‐based nanostructures for dynamic cell regulation and sensing. By merging catalytic DNA with nanomaterials, they enable precise metal‐ion detection, programmable cell–cell interactions, and high‐resolution bioimaging. These advances open new routes to smart theranostic platforms and clinical translation in precision medicine.
Haoyu Fan, Xichen Du, Ruocan Qian
wiley   +1 more source

The Risk of Adverse Birth Outcomes Among Twin Pregnancies After Influenza and Pertussis Vaccinations During Pregnancy: A Data Linkage Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 5, Page 1083-1092, April 2026.
ABSTRACT Objective To compare risks of adverse birth outcomes between maternally vaccinated and unvaccinated twin pregnancies. Design Multi‐jurisdictional data linkage cohort study. Setting All registered births in Queensland (Qld) and Northern Territory (NT), Australia between 1 January 2012 and 31 December 2017.
Kahlee Boyle, Sarah Graham, Michael Binks, Lisa McHugh   +3 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, Volume 116, Issue 4, Page 336-349, April 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source