Results 91 to 100 of about 2,682,884 (340)

Pathogenesis based Precision Therapy for Inborn Errors of Immunity

罕见病研究, 2022
Precision medicine aims at using target therapy on specific diseases by studying the pathogenesis and finding biomarkers. Inborn errors of immunity (IEI) are caused by single gene mutations, providing the perfect human models to study immunology.
SHU Zhou, MAO Huawei
doaj   +1 more source

A control theory approach to optimal pandemic mitigation [PDF]

, 2020
In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic mitigation strategies. We derive rather general conditions for reaching herd immunity while minimizing the costs incurred by the introduction of societal control measures (such as closing schools, social distancing,
arxiv   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Genomes of two Extinct‐in‐the‐Wild reptiles from Christmas Island reveal distinct evolutionary histories and conservation insights

Molecular Ecology Resources, EarlyView., 2023
Abstract Genomics can play important roles in biodiversity conservation, especially for Extinct‐in‐the‐Wild species where genetic factors greatly influence risk of total extinction and probability of successful reintroductions. The Christmas Island blue‐tailed skink (Cryptoblepharus egeriae) and Lister's gecko (Lepidodactylus listeri) are two endemic ...
Tristram O. Dodge, Katherine A. Farquharson, Claire Ford, Lisa Cavanagh, Kristen Schubert, Molly Schumer, Katherine Belov, Carolyn J. Hogg   +7 more
wiley   +1 more source

Stem Cell-Based Disease Models for Inborn Errors of Immunity

Cells, 2021
The intrinsic capacity of human hematopoietic stem cells (hHSCs) to reconstitute myeloid and lymphoid lineages combined with their self-renewal capacity hold enormous promises for gene therapy as a viable treatment option for a number of immune-mediated ...
Aline Zbinden, Kirsten Canté-Barrett, Karin Pike-Overzet, Frank J. T. Staal   +3 more
doaj   +1 more source

Management of Inborn Errors of Immunity in the Genomic Era

Turkish Archives of Pediatrics, 2022
Inborn errors of immunity are a group of rare diseases characterized by a wide variety of manifestations, including unusually severe infections, cancer susceptibility, and exaggerated inflammation that disrupts organ function. As of 2022, over 450 gene deficiencies have been classified under ten categories, where numbers are constantly increasing.
Damla Demir, Doğa, Asnaashari, Kosar, Rezaei, Nima, Özen, Ahmet   +3 more
openaire   +3 more sources

Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies

Advanced Science, EarlyView.
This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty, Saravanabhavan Thangavel   +1 more
wiley   +1 more source

Inborn errors of immunity in paediatric neurology [PDF]

Inborn errors of immunity has become a rapidly evolving medical field, with nearly 500 conditions; as a result, the sheer volume of information can be overwhelming.
Human, Freda P., Smuts, Izelle
core   +1 more source

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity [PDF]

, 2017
Beginning in 1970, a committee was constituted under the auspices of the World Health Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, the International Union of Immunological Societies (IUIS) took the remit of this committee.
Al-Herz, W, Bobby Gaspar, H, Bousfiha, A, Casanova, JL, Chatila, T, Crow, YJ, Cunningham-Rundles, C, Etzioni, A, Franco, JL, Holland, SM, Klein, C, Morio, T, Ochs, HD, Oksenhendler, E, Picard, C, Puck, J, Sullivan, KE, Tang, MLK, Tangye, SG, Torgerson, TR   +19 more
core   +4 more sources

DNA replication–associated inborn errors of immunity

Journal of Allergy and Clinical Immunology, 2023
Inborn errors of immunity are a heterogeneous group of monogenic immunologic disorders caused by mutations in genes with critical roles in the development, maintenance, or function of the immune system. The genetic basis is frequently a mutation in a gene with restricted expression and/or function in immune cells, leading to an immune disorder. Several
Mathijs Willemsen, Frederik Staels, Margaux Gerbaux, Julika Neumann, Rik Schrijvers, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston   +7 more
openaire   +3 more sources