Results 111 to 120 of about 7,049 (225)

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Developmental stuttering with common and complex phenotypes

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the phenotypic spectrum associated with stuttering. Method Individuals with current or resolved developmental stuttering self‐referred. Surveys assessed stuttering characteristics (onset, negative impact, family history) and health (early development, other conditions). Speech and non‐verbal intelligence were assessed using conversation
Sarah E. Horton, Daisy A. Shepherd, Stephanie Siemers, Miya St John, Juliette Catherall, Ingrid E. Scheffer, Angela T. Morgan   +6 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Functional Independence Related to Oral Hygiene and Periodontal Status in Patients With Down Syndrome

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives This study aimed to investigate the relationship between functional independence, oral hygiene habits and periodontal status in patients with Down syndrome (DS). Methods A cross‐sectional observational study was conducted with 49 patients with Down Syndrome. Sociodemographic data, oral hygiene habits and functional independence were
Joana Albuquerque Bastos de Sousa, Kátia Maria Martins Veloso, Monique Maria Melo Mouchrek, Mayra Moura Franco, Cecilia Claudia Costa Ribeiro, Vandilson Pinheiro Rodrigues, Bruno Braga Benatti   +6 more
wiley   +1 more source

A Real‐Life, Multicenter, Retrospective Study on Epidemiological and Clinical Features of Patients With Hidradenitis Suppurativa and Concomitant Down Syndrome

International Journal of Dermatology, EarlyView.
Summary of the clinical characteristics and 2‐year follow‐up of patients with HS and concomitant DS in a multicentre Italian cohort, highlighting earlier HS onset, clinical features, and improved disease severity, quality of life, and pain over follow‐up, supporting early screening and multidisciplinary care of this special population.
Chiara Moltrasio, Luisa Sarno, Giovanni Genovese, Federica Derlino, Dalma Malvaso, Valeria Gaspari, Marina Venturini, Federica Repetto, Gianluca Avallone, Simone Ribero, Elisa Molinelli, Oriana Simonetti, Alessandra Michelucci, Marco Romanelli, Valentina Dini, Marco Manfredini, Cristina Magnoni, Caterina Foti, Silvia Sanna, Laura Atzori, Federico Bardazzi, Riccardo Balestri, Giulia Rech, Paolo Gisondi, Raffaele Dante Caposiena Caro, Iris Zalaudek, Viviana Lora, Luca Fania, Elia Rosi, Stefano Buffon, Carlo Alberto Maronese, Alessandra Cartocci, Pietro Rubegni, Francesca Prignano, Angelo Valerio Marzano   +34 more
wiley   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

The Association Between Pressure Ulcer Development and In‐Hospital Outcomes: A Nationwide Hospitalization‐Level Study in Korea

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To estimate the nationwide incidence of pressure ulcers among hospitalized patients in Korea and to examine their associations with in‐hospital mortality, length of stay, and total inpatient costs. Design A cross‐sectional study using retrospective cohort data.
Seohyun Woo, Seungju Kim, Ji Eun Kim, Sun Jung Kim   +3 more
wiley   +1 more source

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

The Intertwining Between Arthritis and Inborn Errors of Immunity. [PDF]

J Clin Med
Consolini R, Maestrini G, Abu-Rumeileh S, Costagliola G.   +3 more
europepmc   +1 more source

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source