Results 91 to 100 of about 7,759 (229)

Red flags to suspect inborn errors of immunity in patients with autoimmune diseases

Biomédica: revista del Instituto Nacional de Salud
Inborn errors of immunity are monogenic disorders that predispose patients to immune dysregulation, autoimmunity, and infection. Some autoimmune diseases, such as autoimmune cytopenias, systemic lupus erythematosus, and inflammatory bowel diseases, are ...
Natalia Vélez, Juliette De Ávila, Jaime Cortés, Nelson Barrero, Leosirlay Rojas, Juan Manuel Bello, Consuelo Romero-Sánchez   +6 more
doaj   +1 more source

A multicenter, controlled, randomized trial of home‐applied dual‐light photodynamic therapy in stage I to III periodontitis (LumoNorth2022 study)

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a widespread, chronic infection‐triggered inflammatory condition in which professional supportive periodontal care (SPC) and daily oral hygiene form the backbone to reduce the disease activity. Light‐based treatments have shown promising antibacterial effects, but their potential for routine home use has not been ...
Paula Tegelberg, Meeri Ojala, Merja Ylipalosaari, Jori Lindroth, Anna Maria Heikkinen, Hanna Lähteenmäki, Saila Pakarinen, Ismo T. Räisänen, Timo Sorsa, Tommi Pätilä   +9 more
wiley   +1 more source

Early enteral nutrition and neurodevelopment in very low birth weight preterm infants

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Very low birth weight (VLBW) preterm infants are at increased risk of neurodevelopmental impairment. Although human milk may promote brain development, the association between type of feeding at discharge and neurodevelopmental outcomes remains uncertain.
Serafina Perrone, Maria Maddalena Brambilla, Virginia Beretta, Sabrina Moretti, Vincenzo Raitano, Chiara Petrolini, Valentina Dell'Orto, Silvia Carloni   +7 more
wiley   +1 more source

The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Infantile‐onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very‐early‐onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited.
Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram   +2 more
wiley   +1 more source

Disseminated histoplasmosis mimicking autoimmune hepatitis as a trigger of secondary hemophagocytic lymphohistiocytosis in a pediatric patient

JPGN Reports, EarlyView.
Abstract Patients presenting with hemophagocytic lymphohistiocytosis (HLH) are often critically ill, and rapid identification of both HLH and underlying triggers in secondary HLH is essential for successful treatment. We present a case of secondary HLH activated by disseminated histoplasmosis (DH) that mimicked autoimmune hepatitis (AIH) on liver ...
Thomas Ratchford, Talal Al Hendawi, Eumenia Castro, Pelin Cengiz, James Conway, Shelly Cook, Leanne Mansfield, Nicholas Pytel, Christine M. Seroogy, Katelyn Watkin, Jo Wilson, Jonathan Wong, Therese Woodring, Katryn N. Furuya   +13 more
wiley   +1 more source

Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency

JEADV Clinical Practice, EarlyView.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz, Lars Matthies, Andrea Vanegas Ramirez   +2 more
wiley   +1 more source

Two novel kindreds with autosomal recessive STAT2 deficiencySTAT2 deficiency [PDF]

Journal of Human Immunity
Kienapfel et al. report the characterization of two novel mutations underlying STAT2 deficiency in three patients with viral infections and hyperinflammation following live viral vaccines.
Verena Kienapfel, Lotte Cresens, Lucy Bizien, Julia Vasconcelos, Marwa Chbihi, Margarida Guedes, António Marinho, Anneleen Hombrouck, Marjon Wouters, Dylan Laurens, Koji Nakajima, Jean-Laurent Casanova, Jacinta Bustamante, Shen-Ying Zhang, Paul Bastard, Leen Moens, Isabelle Meyts, Giorgia Bucciol   +17 more
doaj   +1 more source

Rash and Non‐Infectious Systemic Inflammation in an Infant With Autosomal Dominant Anhidrotic Ectodermal Dysplasia With Immunodeficiency

JEADV Clinical Practice, EarlyView.
ABSTRACT We present a child with autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency (AD‐EDA‐ID) due to a pathogenic missense variant in NFKBIA presenting with atypical cutaneous manifestations. Our patient was born with a shiny ichthyotic rash on her extremities, developing into a pustulo‐vesicular and papulo‐vesicular rash.
A. Cassidy, S. Collins, I. Farombi‐Oghuvbu, M. McAleer, M. McDermott, M. Slatter, A. Flinn, T. R. Leahy   +7 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source