Results 161 to 170 of about 7,049 (225)

Lymphoproliferation in Inborn Errors of Immunity: Mechanisms, Manifestations and Clinical Management, with a Focus on ALPID. [PDF]

Immunotargets Ther
Gualtiero G, Buso H, Coopmans EC, Milito C, Firinu D, Dalm VASH, Cinetto F.   +6 more
europepmc   +1 more source

Astigmatic changes after Descemet membrane endothelial keratoplasty (DMEK) in decompensated penetrating keratoplasty grafts

Acta Ophthalmologica, Volume 104, Issue 5, Page e516-e529, August 2026.
Abstract Purpose To evaluate the surgery‐induced changes of astigmatism after Descemet membrane endothelial keratoplasty (DMEK) in eyes with failed previous penetrating keratoplasty (PK). Design Retrospective, interventional cohort study based on prospective DMEK database.
Florian Thomas Steinberg, Jithmi Weliwitage, Marie von Berg, Silvia Schrittenlocher, Simona Schlereth, Claus Cursiefen, Björn Bachmann   +6 more
wiley   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, Volume 59, Issue 8, August 2026.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Inborn errors of immunity with DNA repair disorders: at the interface of immune deficiency, immune dysregulation, and malignancy. [PDF]

Front Immunol
Szczawińska-Popłonyk A.
europepmc   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Impaired mucosal IgA response to SARS-CoV-2 in patients with inborn errors of immunity. [PDF]

Front Immunol
Zuo F, Delavari S, Shokri S, Wang Y, Abolnezhadian F, Iranparast S, Salami F, Sharafian S, Chavoshzadeh Z, Rezaei N, Abolhassani H.   +10 more
europepmc   +1 more source

The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence

The Journal of Clinical Hypertension, Volume 28, Issue 8, August 2026.
ABSTRACT Hypertension is a primary risk factor for cardiovascular diseases and all‐cause mortality. Testosterone, the most potent androgen in males, regulates reproduction, metabolism, and erythropoiesis. Hypertension incidence increases with age, whereas testosterone levels decline. Thus, we conducted a study to explore the association between the two
Huan‐dong Wu, Meng‐meng Dong, Biqi Zhang, Zao‐xian Xu, Jiangping Wu, Shen‐Jiang Hu   +5 more
wiley   +1 more source

Pulmonary Manifestations of Inborn Errors of Immunity: Diagnostic and Therapeutic Insights. [PDF]

Life (Basel)
Napiorkowska-Baran K, Cofta S, Treichel P, Tykwinska M, Lis K, Matyja-Bednarczyk A, Szymczak B, Szota M, Slawatycki J, Kulakowski M, Bartuzi Z.   +10 more
europepmc   +1 more source

Enduring autism‐like phenotypes and deregulated hypothalamic prosocial peptides after early‐life exposure to indoor flame retardants in male C57BL/6 mice

Journal of Neuroendocrinology, Volume 38, Issue 8, August 2026.
Abstract Polybrominated diphenyl ethers (PBDEs) are neuroendocrine‐disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterized by abnormal psychosocial functioning and is commonly comorbid with cognitive deficits and sensory abnormalities ...
Elena V. Kozlova, Gwendolyn M. Gonzalez, Maximillian E. Denys, Anthony E. Bishay, Roberto Gutierrez, Jack Reid, Julia M. Krum, Gregory Lampel, Naran Luvsanravdan, Kayhon M. Rabbani, Jordan Tu, Luis Campoy, Laura M. Anchondo, Crystal N. Luna, Duraan S. Olomi, Eduardo Monarrez, Valeria Carrillo, Jasmin D. Tran, Damon Platt, Yash Korde, Bhuvaneswari D. Chinthirla, Maher Blaibel, Simon Kim, Gladys Chompre, Allison L. Phillips, Heather M. Stapleton, Bernhard Henkelmann, Karl‐Werner Schramm, Margarita C. Curras‐Collazo   +28 more
wiley   +1 more source

Lymphoproliferation in inborn errors of immunity: From challenging diagnosis to histologic revision. [PDF]

J Hum Immun
Moratti M, Rivalta B, Cardoni A, Santilli V, Attardi E, Manno EC, Ciudino R, Di Cesare S, Cifaldi C, Mengoli C, Muratore E, Naviglio S, Selva P, Ferrari S, Di Matteo G, Broccoli A, Cotugno N, Amodio D, Masetti R, Facchini E, Zinzani PL, Lanari M, Milito C, Tommasini A, De Vito R, Finocchi A, Alaggio R, Sabattini E, Cancrini C, Conti F.   +29 more
europepmc   +1 more source