Results 81 to 90 of about 2,682,884 (340)

Future perspectives of newborn screening for inborn errors of immunity [PDF]

, 2021
Newborn screening (NBS) programs continue to expand due to innovations in both test methods and treatment options. Since the introduction of the T-cell receptor excision circle (TREC) assay 15 years ago, many countries have adopted screening for severe ...
Blom, M., Bredius, R., Burg, M. van der
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Frequency of otitis media with effusion among children aged 1–5 years presenting to immunization center of tertiary care hospitals, Rawalpindi

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 8, Issue 4, Page 315-320, December 2022., 2022
Abstract Objective We conducted this study to assess the etiopathogenic relation of otitis media with effusion (OME) in a group of children aged 1–5 years among the local population of Rawalpindi. Methods This was a cross‐sectional retrospective study.
Nida Riaz, Muhammad Ajmal, Muhammad Sheharyar Khan   +2 more
wiley   +1 more source

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

Advanced Materials, EarlyView.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo   +19 more
wiley   +1 more source

Consensus Middle East and North Africa Registry on Inborn Errors of Immunity [PDF]

, 2021
Background: Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications.
Abolnezhadian, F, Adeli, M, Aghamohammadi, A, Ahanchian, H, Ahmadiafshar, A, Akbari, H, Al-Ahmed, M, Al-Nesf, M, Al-Tamemi, S, Aleyasin, S, Amin, R, Arshi, S, Attal, N, Azizi, G, Babaie, D, Barbouche, R, Baris, S, Bazargan, N, Bazregari, S, Behmanesh, F, Behniafard, N, Belaid, B, Belbouab, R, Bemanian, MH, Boukari, R, Bousfiha, A, Chavoshzadeh, Z, Cheraghi, T, Dabbaghzadeh, A, Darabi, B, Darabi, K, Darougar, S, Delavari, S, Djenouhat, K, Djidjik, R, Elnagdy, MH, Eslamian, MH, Fallahpour, M, Faridhosseini, R, Fathi, SM, Fayezi, A, Ferhani, Y, Genel, F, Ghaffari, J, Ghalebaghi, B, Ghasemi, R, Gulez, N, Hassen, A, Heidarzadeh, M, Irani, C, Jabbari-Azad, F, Kalantari, A, Kalmarzi, RN, Karakoc-Aydiner, E, Kashef, S, Kechout, N, Khalili, A, Khayatzadeh, A, Khoshkhui, M, Kilic, SS, Kose, H, Kutukculer, N, Ladj, S, Mahdaviani, SA, Mansouri, M, Megarbane, A, Mehawej, C, Mesdaghi, M, Moghtaderi, M, Mohammadzadeh, I, Molatefi, R, Momen, T, Mortazavi, SH, Nabavi, M, Nasrullayeva, G, Ozen, A, Quinn, J, Reisli, I, Rezaei, N, Rizk, R, Sadeghi-Shabestari, M, Safari, M, Saidani, K, Sajedi, V, Shafiei, A, Shakerian, B, Sherkat, R, Shirkani, A, Sobh, A, Soheili, H, Tafaroji, J, Taghvaei, B, Tahiat, A, Tavakol, M, Tavassoli, M, Topyildiz, E, Torabizadeh, M, Yazdani, R, Zandieh, F, Zandkarimi, M   +99 more
core  

Gene- and Disease-Based Expansion of the Knowledge on Inborn Errors of Immunity

Frontiers in Immunology, 2019
The recent report of the International Union of Immunological Societies (IUIS) has provided the categorized list of 354 inborn errors of immunity. We performed a systematic analysis of genes and diseases from the IUIS report with the use of the OMIM ...
Lyubov E. Salnikova, Lyubov E. Salnikova, Lyubov E. Salnikova, Ekaterina V. Chernyshova, Lyudmila A. Anastasevich, Sergey S. Larin   +5 more
doaj   +1 more source

Immune Defense: A Novel Adversarial Defense Mechanism for Preventing the Generation of Adversarial Examples [PDF]

arXiv, 2023
The vulnerability of Deep Neural Networks (DNNs) to adversarial examples has been confirmed. Existing adversarial defenses primarily aim at preventing adversarial examples from attacking DNNs successfully, rather than preventing their generation. If the generation of adversarial examples is unregulated, images within reach are no longer secure and pose
arxiv  

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Health service use and predictors of high health service use among adults experiencing homelessness: a retrospective cohort study

Australian and New Zealand Journal of Public Health, Volume 46, Issue 6, Page 896-902, December 2022., 2022
Abstract Objective: To describe the characteristics and cost of health service use of a cohort of 2,140 people attending homeless hostel clinics, and identify predictors of high health service use and time to readmission. Method: A retrospective cohort study of 2,140 adults who attended a homeless hostel clinic and were hospitalised in New South Wales (
Rebecca J. Mitchell, Eyal Karin, Joseph Power, Hayden Foung, Naidene Jones, Olav Nielssen   +5 more
wiley   +1 more source