A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. [PDF]
PLoS ONE, 2009 Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Richard Williams +13 more
doaj +5 more sources
The genetic architecture of NAFLD among inbred strains of mice. [PDF]
Elife, 2015 To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a diet
Hui ST +15 more
europepmc +2 more sources
Inbreeding Ratio and Genetic Relationships among Strains of the Western Clawed Frog, Xenopus tropicalis. [PDF]
PLoS ONE, 2015 The Western clawed frog, Xenopus tropicalis, is a highly promising model amphibian, especially in developmental and physiological research, and as a tool for understanding disease.
Takeshi Igawa +10 more
doaj +7 more sources
Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. [PDF]
PLoS Genet, 2015 Common forms of atherosclerosis involve multiple genetic and environmental factors. While human genome-wide association studies have identified numerous loci contributing to coronary artery disease and its risk factors, these studies are unable to ...
Bennett BJ +16 more
europepmc +2 more sources
Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains
Frontiers in Physiology, 2017 Changes in cardiorespiratory fitness in response to a standardized exercise training protocol differ substantially between individuals. Results from cross-sectional, twin, and family studies indicate genetics contribute to individual differences in both ...
Joshua J. Avila +2 more
doaj +2 more sources
Development of SNP markers for C57BL/6N-derived mouse inbred strains. [PDF]
Exp Anim, 2015 C57BL/6N inbred mice are used as the genetic background for producing knockout mice in large-scale projects worldwide; however, the genetic divergence among C57BL/6N-derived substrains has not been verified.
Mekada K +3 more
europepmc +2 more sources
Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers [PDF]
G3: Genes, Genomes, Genetics, 2016 Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Here, we report the whole-genome sequencing of two wild-derived mouse inbred strains, LEWES/EiJ and ZALENDE/EiJ ...
Andrew P. Morgan +6 more
doaj +2 more sources
A general Bayesian approach to analyzing diallel crosses of inbred strains. [PDF]
Genetics, 2012 The classic diallel takes a set of parents and produces offspring from all possible mating pairs. Phenotype values among the offspring can then be related back to their respective parentage.
Lenarcic AB +3 more
europepmc +2 more sources
Inbred mouse strains and genetic stability: a review
Animal, 2011 Inbred mice were essential animal models for scientific research during the 20th century and will contribute decisive results in the current and next centuries.
J. Casellas
doaj +2 more sources
The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. [PDF]
Genome Res, 2013 Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their genomes are derived predominantly from the Western European subspecies Mus musculus domesticus, with the remaining sequences derived
Takada T +15 more
europepmc +2 more sources