Results 91 to 100 of about 169,377 (260)

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS

Медицинская иммунология, 2014
. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium ...
D. V. Balunets, L. N. Nesterenko, Yu. S. Romanova, Yu. S. Alyapkina, N. I. Kolkova, A. S. Apt   +5 more
doaj   +3 more sources

High-Resolution Maps of Mouse Reference Populations

G3: Genes, Genomes, Genetics, 2017
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J × DBA/2J, ILS/IbgTejJ × ISS ...
Petr Simecek, Jiri Forejt, Robert W. Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E. Johnson, Beth Bennett, Christian F. Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, Gary A. Churchill   +11 more
doaj   +1 more source

Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging

Aging Cell, EarlyView.
The prevailing view is that the age‐related decline of B lymphopoiesis is due to increased inhibitory signals in the marrow environment. Our data show that the loss of salutary ones, such as those from bone, primarily drives the loss of B cell progenitors with age.
Erin Baker, Encarnacion Montecino‐Rodriguez, Shili Xu, Sotirios Tetradis, Adrien Rouault, Oscar I. Estrada, Kenneth Dorshkind   +6 more
wiley   +1 more source

Innate immune basis for rift valley fever susceptibility in mouse models [PDF]

, 2017
Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the
Bruhns, Pierre, Flamand, Marie, Godon, Ophélie, Jouvion, Grégory, Lathan, Rashida, Malissen, Marie, Panthier, Jean-Jacques, Simon-Chazottes, Dominique   +7 more
core   +2 more sources

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, EarlyView.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?

Frontiers in Psychiatry
Under conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed, Cheryl Reed, Tamara J. Phillips, Tamara J. Phillips, Tamara J. Phillips   +4 more
doaj   +1 more source

Dysfunctional play and dopamine physiology in the Fischer 344 rat

, 2011
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain.
Akopian, Akopian, Akopian, Alcaro, Alessandri, Almeida, Baldwin, Bamford, Basar, Beatty, Beatty, Bell, Berridge, Breier, Broderick, Burgdorf, Burgdorf, Burghardt, Burghardt, Burghardt, Cadoni, Cadoni, Calabresi, Chambers, Cheng, Cordier, Crawford, Crawley, Cynthia A. Crawford, Davis, Depoortere, Fagen, Feifel, Field, Fleckenstein, Gainetdinov, Garnik Akopian, Garris, Geyer, Glowa, Gomez-Serrano, Gonon, Gordon, Guitart, Gulley, Guo, Gurden, Hariri, Harris, Helmeste, Huang, Huang, Hubbard, Humphries, Ikemoto, John P. Walsh, Kerr, Knutson, Kolomiets, Kosten, Leblois, Leipold, McGraw La, Meaney, Miles, Niesink, Panksepp, Panksepp, Panksepp, Panksepp, Panksepp, Patel, Patel, Pellegrini, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Petzinger, Pliszka, Reif, Robinson, Romeo, Sagvolden, Schulte, Sills, Siviy, Siviy, Siviy, Siviy, Siviy, Siviy, Skuse, Smith, Smith, Spear, Spinka, Stamford, Stephen M. Siviy, Stohr, Sulzer, Surmeier, Swerdlow, Swerdlow, Swerdlow, Tang, Terranova, Trezza, Trezza, Trezza, Trezza, Tripp, Van den Berg, Vanderschuren, Vanderschuren, Vanderschuren, Varty, Villar, Volkow, Voorn, Walker, Young   +126 more
core   +1 more source

Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals

Biological Reviews, EarlyView.
ABSTRACT The ability of individuals to cope with their environment, and therefore the likelihood that they survive and pass on their genes (i.e. fitness), is largely determined by physiological state. Tracking physiological state in wild animals, however, is challenging.
Paul Jerem, L. Michael Romero
wiley   +1 more source

Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice [PDF]

, 2020
Stephen E. Wilkie, Lorna Mulvey, William A. Sands, Diana Marcu, Roderick N. Carter, Nicholas M. Morton, Christopher Hine, James R. Mitchell, Colin Selman   +8 more
openalex   +1 more source