Results 11 to 20 of about 2,324,041 (334)

Phylogenetics of rat inbred strains

open access: yesMammalian Genome, 2003
Laboratory rats (Rattus norvegicus) have played animportant role in biomedical research for over 100years with more than 200 strains bred as physiologi-cal models of human disease (Lindsey 1979; Steenet al. 1999; Kwitek-Black and Jacob 2001). Unlikemouse inbred strains, little is known about rela-tionships among rat strains (Festing 1979).
Michael A. Thomas   +4 more
semanticscholar   +4 more sources

Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection

open access: yesScientific Reports, 2023
Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice ...
Kishore R. Alugupalli   +11 more
doaj   +1 more source

The Effect of Population Structure on Murine Genome-Wide Association Studies

open access: yesFrontiers in Genetics, 2021
The ability to use genome-wide association studies (GWAS) for genetic discovery depends upon our ability to distinguish true causative from false positive association signals.
Meiyue Wang   +7 more
doaj   +1 more source

In silico candidate variant and gene identification using inbred mouse strains [PDF]

open access: yesPeerJ, 2021
Mice are the most widely used animal model to study genotype to phenotype relationships. Inbred mice are genetically identical, which eliminates genetic heterogeneity and makes them particularly useful for genetic studies.
Matthias Munz   +4 more
doaj   +2 more sources

The Mouse Universal Genotyping Array: From Substrains to Subspecies

open access: yesG3: Genes, Genomes, Genetics, 2016
Genotyping microarrays are an important resource for genetic mapping, population genetics, and monitoring of the genetic integrity of laboratory stocks.
Andrew P. Morgan   +22 more
doaj   +1 more source

Analysis of structural variation among inbred mouse strains

open access: yesBMC Genomics, 2023
Background ‘Long read’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases.
Ahmed Arslan   +10 more
doaj   +1 more source

Variability in empathic fear response among 11 inbred strains of mice

open access: yesGenes, Brain and Behavior, 2016
Empathy is an important emotional process that involves the ability to recognize and share emotions with others. We have previously developed an observational fear learning (OFL) behavioral assay to measure empathic fear in mice. In the OFL task, a mouse
S. Keum   +6 more
semanticscholar   +1 more source

Rift Valley Fever Virus Is Lethal in Different Inbred Mouse Strains Independent of Sex

open access: yesFrontiers in Microbiology, 2020
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting humans and livestock in Africa and the Arabian Peninsula. The majority of human cases are mild and self-limiting; however, severe cases can result in hepatitis, encephalitis, or hemorrhagic
Haley N. Cartwright   +5 more
doaj   +1 more source

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