Results 21 to 30 of about 2,324,041 (334)
Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]
The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E.+1 more
core +1 more source
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza+7 more
wiley +1 more source
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A+6 more
core +1 more source
Genetic factors influence Fetal Alcohol Spectrum Disorders (FASD) in both humans and animals. Experiments using inbred and selectively bred mouse stocks that controlled for 1) ethanol dose, 2) maternal and fetal blood ethanol levels, and 3) fetal ...
David eGilliam
doaj +1 more source
Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]
Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R.+4 more
core +2 more sources
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta+8 more
core +17 more sources
QTLs for bone mineral density of femurs and tibias in recombinant inbred strains derived from C57BL/6J and DBA/2J inbred strains [PDF]
Wang Lishi+9 more
doaj +2 more sources
The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]
The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman+10 more
core +3 more sources
The Mouse Genomes Project is an ongoing collaborative effort to sequence the genomes of the common laboratory mouse strains. In 2011, the initial analysis of sequence variation across 17 strains found 56.7 M unique single nucleotide polymorphisms (SNPs ...
A. Doran+5 more
semanticscholar +1 more source
The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. [PDF]
Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation.
Hallgrímsson, Benedikt+4 more
core +1 more source