Results 51 to 60 of about 5,619,681 (327)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

Frontiers in Cell and Developmental Biology, 2022
Immunotherapy has developed rapidly and has gradually become one of the important methods for treatment of gastric cancer (GC). The research on tumor infiltrating immune cells (TIICs) and immune-related genes in the tumor microenvironment (TME) greatly ...
An Zhi Zhang, An Zhi Zhang, Xin Yuan, Wei Hua Liang, Hai Jun Zhang, Ya Li, Yu Fang Xie, Jiang Fen Li, Chen Hao Jiang, Fan Ping Li, Xi Hua Shen, Li Juan Pang, Hong Zou, Wen Hu Zhou, Feng Li, Feng Li, Jian Ming Hu   +16 more
doaj   +1 more source

The immersion incident [PDF]

Anaesthesia, 1975
The ever increasing participation in aquatic recreational activities is a major factor in the increasing number of deaths due to accidental immersion. Some of these deaths occur while undergoing resuscitative efforts immediately following rescue, on admission to hospital, or even up to 19 days after the immersion incident. Drowning, either acute or its
J. F. Rivers, F. St C. Golden
openaire   +3 more sources

Influence of cavity lifetime on high-finesse microcavity two-photon absorption photodetectors [PDF]

, 2007
For optical pulse incidence as compared with continuous-wave incidence, the enhancement of two-photon absorption inside a high-finesse planar microcavity is reduced, the pulse inside the cavity and the cavity spectrum are broadened.
Barry, Liam P., Bradley, Ann Louise, Donegan, John Francis, Guo, Wei Hua, Lynch, Michael, O'Dowd, John   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Comparative effectiveness of monotherapy vs. combination therapy for postoperative central nervous system infections in neurosurgical patients: a retrospective cohort study

BMC Infectious Diseases
Background Although clinical guidelines recommend vancomycin-based combination therapy for patients with postoperative intracranial infections in neurosurgery, the trend of global bacterial resistance and the management of antimicrobial agents have made ...
Muyun Li, Wei Meng, Linna An, Xiaoqi Lin, Shangjie Yang, Qiang Fu, Qiuxia Shi, Dongfeng Li, Jie Wang, Jianhua Wang, Yubo Wang   +10 more
doaj   +1 more source

Aberrant activation of CYR61 enhancers in colorectal cancer development

Journal of Experimental & Clinical Cancer Research, 2019
Background High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation has been shown to correlate with expression of key genes involved in cancer ...
Lingzhu Xie, Xuhong Song, Hao Lin, Zikai Chen, Qidong Li, Tangfei Guo, Tian Xu, Ting Su, Man Xu, Xiaolan Chang, Long-Kun Wang, Bin Liang, Dongyang Huang   +12 more
doaj   +1 more source

Angle of incidence [PDF]

The Aeronautical Journal, 1901
If the term ‘angle of incidence’, so frequently used in aeronautical discussions, could be confined to a single definite meaning, viz., the angle at which aeroplane and wind actually meet, much error and confusion would be averted. But many of the best writers use this term loosely and inexactly, with the result that their calculations and explanations
openaire   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Experimental study on the optimization of ANM33 release in foam cells

Open Life Sciences, 2023
Given the miR-33’s mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 ...
Yuan Chen, Liu Liyun, Tayier Baihetiya, Ma Ting, Guan Lina, Mu Yuming, Li Yanhong   +6 more
doaj   +1 more source