Results 71 to 80 of about 654,333 (264)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Formosan Journal of Musculoskeletal DisordersBackground: Postoperative leg length discrepancy (LLD) and dislocation are the most common complications after total hip replacement. Modern technology with three-dimensional (3D) planning can be very helpful for total hip arthroplasty to restore the ...
Meng-Hsueh Tsai +5 more
doaj +1 more source
, 2019 The afterglow emission of some gamma-ray bursts (GRBs) show a shallow decay (plateau) phase implying continuous injection of energy. The source of this energy is very commonly attributed to the spin-down power of a nascent millisecond magnetar.
Andaç, I. Ceyhun +4 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 1970 The inclination of the earth\u27s equatorial plane to the plane of the earth\u27s orbit around the sun, termed the obliquity of the ecliptic by astronomer\u27s, is approximately equal to 23º27\u27 of arc.
Beaman, Ralph G.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
К вопросу эволюции звуковысотных систем: Вагнер-Лист-Регер
Вестник музыкальной науки, 2018 Процесс преобразования романтического музыкального словаря в сторону кардинального слома звуковысотной координации, состоявшейся в начале XX столетия, вызывает интерес ученых-музыковедов уже не одно поколения.
Аймаканова, Анастасия
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Gen Z consumers’ inclination to engage in brand relationships in Metaverse – an empirical approach
Journal of Modern ScienceObjectives The purposes of this study were to recognize correlates with the inclination of Gen Z customers to build brand relationship in Metaverse, as well as to recognize and categorise factors influencing Gen Z’s inclination to build and maintain ...
Anna Dewalska-Opitek +1 more
doaj +1 more source