Results 81 to 90 of about 654,333 (264)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluation of Thermal Transfer Efficiency and Nonlinear Shear Effects on Flow Modulation in a Flexible Microfluidic Heat Transfer System

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
This study examines the thermal transfer performance of a microfluidic heat transfer system, with a focus on the interplay between flow orientation, flexibility, and nonlinear shear dilution/enhancement effects.
Uchenna Uka, Edwin Esekhaigbe, Joseph Onyeka Emegha, Godswill Kalu   +3 more
doaj   +1 more source

Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans"

eLife, 2018
A diverse array of species on the planet employ the Earth's magnetic field as a navigational aid. As the majority of these animals are migratory, their utility to interrogate the molecular and cellular basis of the magnetic sense is limited.
Lukas Landler, Simon Nimpf, Tobias Hochstoeger, Gregory C Nordmann, Artemis Papadaki-Anastasopoulou, David A Keays   +5 more
doaj   +1 more source

Structural damage detection of elevated circular water tank and its supporting system using geodetic techniques

Geodesy and Cartography, 2020
Water is the main source of daily life for everyone and everywhere in the world.Sufficient water distribution depends on the place and design of water tank in certain areas.Water storage tanks are relatively flexible structures and they can tolerate ...
Zaki Zeidan, Ashraf A.A. Beshr, Sara Sameh   +2 more
doaj   +1 more source

Coorbital capture at arbitrary inclination

, 2017
The process of capture in the coorbital region of a solar system planet is studied. Absolute capture likelihood in the 1:1 resonance is determined by randomly constructed statistical ensembles numbering $7.24\times 10^5$ of massless asteroids that are ...
Morais, Helena, Namouni, Fathi
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Misalignment of the microquasar V4641 Sgr (SAX J1819.3--2525)

, 2008
In the microquasar V4641 Sgr the spin of the black hole is thought to be misaligned with the binary orbital axis. The accretion disc aligns with the black hole spin by the Lense-Thirring effect near to the black hole and further out becomes aligned with ...
Bardeen, Blandford, Brandt, Butt, Chaty, Fabian, Fabian, Garcia, Greene, Hjellming, Hjellming, in't Zand, in't Zand, J. E. Pringle, Laor, Maccarone, Maitra, Markwardt, Martin, Martin, Martin, Miller, Miller, Mirabel, Narayan, Nishikawa, Orosz, Orosz, Orosz, Pringle, Rebecca G. Martin, Reis, Revnivtsev, Reynolds, Reynolds, Rubens C. Reis, Scheuer, Shakura, Wijers, Zhang   +39 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Geomagnetic measurements in Latvia

Geodesy and Cartography, 2012
The knowledge of the Earth's magnetic field elements and their dynamic fluctuations over the area concerned are important and can be used for many practical purposes in various fields, including Geodesy and Cartography. Earth's magnetic field tends to
Ljuba Shuljakova
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source