Results 171 to 180 of about 277,495 (246)

Inhaled Micro- and Nanoplastics as Environmental Modifiers of Lung Carcinogenesis: Mechanistic Insights and Evidence Synthesis. [PDF]

J Xenobiot
Andrikopoulou C, Koletsis NE, Leivaditis V, Mulita F, Mitsos S, Tomos P, Panagiotopoulos I, Androutsopoulou V, Kostakis MG, Thomaidis NS, Koletsis E.   +10 more
europepmc   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Global, regional and national burden of tracheal, bronchus and lung cancer attributable to occupational carcinogens from 1990 to 2021 and projections to 2050: A finding from the global burden of disease study 2021 and Mendelian randomization. [PDF]

Sci Prog
Ma S, Lin C, Guo F, Ning Y, Tang J, He H, Qiang G.   +6 more
europepmc   +1 more source

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

ExposoGraph: An Interactive Platform for Carcinogen Bioactivation and Detoxification Pathway Visualization. [PDF]

Med Oncol
Kazi JU, Pienta KJ.
europepmc   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

Cytotoxic and Genotoxic Effects in Buccal Cells of Sandstone Quarry Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mineral extraction poses significant occupational health risks, particularly from respirable crystalline silica exposure. Sandstone quarrying generates substantial dust, yet evidence of its genotoxic effects remains limited. This study investigated cytogenotoxic damage in sandstone quarry workers from southern Brazil using the buccal ...
Ana Carolina de Quadros Duarte, Maria Isabela Toniazzo, Rayne Vallada da Luz, Cleisson Guimarães Bueno, Daniela Müller de Quevedo, Luciano Basso da Silva, Daiane Bolzan Berlese   +6 more
wiley   +1 more source

Combined Occupational Exposure to Lead and Other Metals and Risk of Lung Cancer. [PDF]

Med Lav
Boffetta P, Zaridze D, Świątkowska B, Pándics T, Lissowska J, Fabiánová E, Field JK, Mates D, Schejbalová M, Foretova L, Janout V, Mukheria A, Yang C, Seyyedsalehi MS.   +13 more
europepmc   +1 more source

Bioelectrochemical single reactor for reductive and oxidative removal of trichloroethylene from contaminated groundwater

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Chlorinated aliphatic hydrocarbons such as trichloroethylene (TCE) are persistent groundwater contaminants due to improper disposal and low biodegradability. This work presents an innovative bioelectrochemical system for the integrated reductive/oxidative removal of TCE from contaminated water, implemented in a single tubular ...
Maria Presutti, Geremia Sassetto, Angela Marchetti, Giulia Simonetti, Marco Petrangeli Papini, Marco Zeppilli   +5 more
wiley   +1 more source

Tumour promotion through the lens of evolution. [PDF]

Nature
Lopez-Bigas N, Kandyba E, Gonzalez-Perez A, Brennan P, Balmain A.   +4 more
europepmc   +1 more source