Results 121 to 130 of about 7,022,792 (370)
Frontiers in Bioengineering and Biotechnology, 2019 State of the art microbial recombinant protein production is regularly performed in fed-batch based cultivations. However, these cultivations suffer from highly time-dependent changes in productivity and product quality, leading to high variations in the
Julian Kopp +6 more
doaj +1 more source
Temperature and Crowding Effects on Virus Manifestation in Neodiprion Sertifer (Hymenoptera: Diprionidae) Larvae [PDF]
, 2017 Temperature and (or) crowding (larval density) functioned as stressors in the induction of symptoms associated with the nucleopolyhedrosis virus of the European pine sawfly, Neodiprion sertifer, Subsamptes of larvae maintained at 30 and 35°C, with three ...
Coppel, H. C +2 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum [PDF]
, 2015 The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin inclusion bodies (FENIB ...
Dalton, Lucy +13 more
core +3 more sources
Microbial Cell Factories, 2013 BackgroundAdhesins of pathogens recognise the glycans on the host cell and mediate adherence. They are also crucial for determining the tissue preferences of pathogens. Currently, glyco-nanomaterials provide potential tool for antimicrobial therapy.
Klaudia Talafová +3 more
semanticscholar +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Rigorous bounds on the effective moduli of composites and inhomogeneous bodies with negative-stiffness phases [PDF]
, 2014 We review the theoretical bounds on the effective properties of linear elastic inhomogeneous solids (including composite materials) in the presence of constituents having non-positive-definite elastic moduli (so-called negative-stiffness phases). We show
Kochmann, Dennis M., Milton, Graeme W.
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Feeder-supported in vitro exercise model using human satellite cells from patients with sporadic inclusion body myositis [PDF]
, 2022 Yuqing Li +12 more
openalex +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis [PDF]
, 2003 A 36-year-old Chinese man presented to the Queen Mary Hospital in August 1999 with a 2-week history of jaundice due to propylthiouracil treatment for thyrotoxicosis. He had previously received carbimazole but had developed an urticarial skin rash after 2
Chan, AOO +4 more
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