Results 71 to 80 of about 222,372 (293)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Protein folding and the formation of inclusion bodies

浙江大学学报. 农业与生命科学版, 2004
Newly synthesized polypeptide chains must be folded and assembled into unique three-dimensional structures in order to become functionally active. In the folding process, many misfolded proteins maybe produced and thus accumulate as aggregates.
JING Ming-yan, SUN Jian-yi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Inclusion bodies in loggerhead erythrocytes are associated with unstable hemoglobin and resemble human Heinz bodies.

, 2011
The aim of this study was to clarify the role of the erythrocyte inclusions found during the hematological screening of loggerhead population of the Mediterranean Sea.
Flegra Bentivegna, Alessandra Pica, FERRETTI L, Annalisa Di Santi, Filomena Basile, DI SANTI, ANNALISA, BASILE, FILOMENA, PICA, ALESSANDRA, CALDORA M, BENTIVEGNA F, Mercedes Caldora, Luigi Ferretti   +11 more
core   +1 more source

Learning about protein solubility from bacterial inclusion bodies

Microbial Cell Factories, 2009
The progressive solving of the conformation of aggregated proteins and the conceptual understanding of the biology of inclusion bodies in recombinant bacteria is providing exciting insights on protein folding and quality.
García-Fruitós Elena, González-Montalbán Nuria, Martínez-Alonso Mónica, Villaverde Antonio   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Luminescent Conjugated Oligothiophenes for Sensitive Fluorescent Assignment of Protein Inclusion Bodies

, 2013
Small hydrophobic ligands identifying intracellular protein deposits are of great interest, as protein inclusion bodies are the pathological hallmark of several degenerative diseases.
Klingstedt, Therése,, Askanas, Valerie,, Danielsson, Olof,, Blechschmidt, Cristiane,, Prokop, Stefan,, Nogalska, Anna,, King Engel, W,, Nilsson, K Peter R,, Häggqvist, Bo,, Heppner, Frank L.,   +9 more
core   +1 more source

Quality control of inclusion bodies in Escherichia coli

Microbial Cell Factories, 2010
Background Bacterial inclusion bodies (IBs) are key intermediates for protein production. Their quality affects the refolding yield and further purification.
Schweder Thomas, Hecker Michael, Lin Hongying, Büttner Knut, Urlacher Vlada, Breitenstein Antje, Jürgen Britta, Neubauer Peter   +7 more
doaj   +1 more source