Results 221 to 230 of about 6,627,008 (361)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

XR Technologies in Inclusive Education for Neurodivergent Children: A Systematic Review 2020-2024. [PDF]

Children (Basel)
Valverde Olivares B, Muñoz Araya L, Valín JL, Jarpa Azagra M, Hidalgo Escobar R, Cuevas Quezada I, Galleguillos Ketterer C.   +6 more
europepmc   +1 more source

THE ESSENCE OF THE PHENOMEN OF INCLUSIVE EDUCATION

, 2021
Maria Lopatina
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Navigating Barriers and Building Pathways: Inclusive Education for Children with Special Needs. [PDF]

F1000Res
Aldhilan D, Rafiq S, Afzal A.
europepmc   +1 more source

The Needs Analysis of Increasing Teachers’ Pedagogical Competences of Inclusive Education [PDF]

, 2018
M.Pd. Sukinah, Cece Rakhmat, Endang Rochyadi, Mr Sunardi   +3 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pre-service teachers' empathy and attitudes toward inclusive education-The chain mediating role of teaching motivation and inclusive education efficacy. [PDF]

PLoS One
Jiang N, Li H, Ju SY, Kong LK, Li J.
europepmc   +1 more source

Education for all in action: Measuring teachers' competences for inclusive education. [PDF]

PLoS One, 2023
Vantieghem W, Roose I, Goosen K, Schelfhout W, Van Avermaet P.   +4 more
europepmc   +1 more source

ANALYSIS OF THE PROBLEM OF FORMATION OF INCLUSIVE COMPETENCES IN FUTURE TEACHERS OF PRE-SCHOOL EDUCATION INSTITUTIONS

, 2022
Yu. Yu. Buhera, O. O. Smotrova
openalex   +2 more sources