Results 91 to 100 of about 1,015,115 (264)

Finding Informative Skyline Results Over Incomplete Data With Threshold-Based Bucket Skyline Algorithm

open access: yesIEEE Access
Skyline queries which return objects that are not dominated by any other objects, have been integrated into various real-world database applications. However, the presence of incomplete data in databases, may lead into cyclic dominance relation that none
Zhang Xiaowei   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Data visualization for incomplete data

open access: yes, 2023
Missing data are ubiquitous in the social and human data sciences. Computational pipelines that accommodate incomplete data require exploration and evaluation of the missingness. The R package ggmice enables data analysts to visualize incomplete and imputed data.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Polyester Melt Characteristic Viscosity Prediction Method Under Incomplete Data

open access: yesShanghai Jiaotong Daxue xuebao
Characteristic viscosity is a key indicator of the quality of polyester melts, whose accurate prediction can help to identify potential quality problems of polyester melts in advance, adjust the process parameters in time and reduce enterprise losses ...
BI Jinmao, ZHANG Peng, ZHANG Jie, ZHAO Chuncai, CUI Li
doaj   +1 more source

Incomplete Data and Potential Risks of Drugs in People with Obesity. [PDF]

open access: yesCurr Obes Rep, 2023
Apovian CM   +4 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Noisier2Inverse: Self-Supervised Learning for Image Reconstruction With Correlated Noise

open access: yesIEEE Access
We propose Noisier2Inverse, a correction-free, self-supervised deep learning method for general inverse problems. Our approach learns a reconstruction function without requiring ground truth data and is applicable in settings where measurement noise is ...
Nadja Gruber   +5 more
doaj   +1 more source

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