Results 111 to 120 of about 2,525,472 (291)
Algorithms, 2019 We study two problems in computational phylogenetics. The first is tree compatibility. The input is a collection of phylogenetic trees over different partially-overlapping sets of species.
David Fernández-Baca, Lei Liu
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FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
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IEEE AccessSkyline queries which return objects that are not dominated by any other objects, have been integrated into various real-world database applications. However, the presence of incomplete data in databases, may lead into cyclic dominance relation that none
Zhang Xiaowei +4 more
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
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Learning with Missing or Incomplete Data [PDF]
, 2009 The problem of learning with missing or incomplete data has received a lot of attention in the literature [6,10,13,21,23]. The reasons for missing data can be multi-fold ranging from sensor failures in engineering applications to deliberate withholding of some information in medical questioners in the case of missing input feature values or lack of ...
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Data visualization for incomplete data
, 2023 Missing data are ubiquitous in the social and human data sciences. Computational pipelines that accommodate incomplete data require exploration and evaluation of the missingness. The R package ggmice enables data analysts to visualize incomplete and imputed data.
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
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The Dueling Hazards of Incomplete Revascularization and Incomplete Data [PDF]
Circulation, 2006 Although the survival benefit of complete revascularization after bypass surgery is well documented, the importance of opening all stenotic or occluded vessels during percutaneous coronary intervention (PCI) is less certain. On the contrary, much data support targeting only the culprit vessel during PCI. A strategy of “ischemic-driven revascularization”
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