Results 101 to 110 of about 1,015,115 (264)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Assessing data completeness in the international society for the study of pleura and peritoneum (ISSPP) PIPAC database: a multicenter evaluation from 2020–2024

Pleura and Peritoneum
In 2020, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) reached stage 2b of the IDEAL framework and a prospective international PIPAC database was launched in June 2020 by the International Society for the Study of the Pleura and Peritoneum ...
Jørgensen Magnus Skov, Hansen Pernille Shjødt, Fristrup Claus Wilki, Hübner Martin, So Jimmy, Ezanno Anne-Cecile, Hewett Peter, Ruiz-Marin Miguel, Rezniczek Günther, Düzgün Özgül, Pocard Marc, Casella Francesco, Lay Laura, Aral Marisa, Jäger Tarkan, Laminger Felix, Glehen Oliver, Goutard Claire-Angéline, Villeneuve Laurent, Di Giorgio Andrea, Mortensen Michael Bau   +20 more
doaj   +1 more source

Ambiguities, Built-In Biases, and Flaws in Big Data Insight Extraction

Information
I address the challenge of extracting reliable insights from large datasets using a simplified model that illustrates how hierarchical classification can distort outcomes. The model consists of discrete pixels labeled red, blue, or white.
Serge Galam
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A Multi-Source Domain Adaptation Method for Bearing Fault Diagnosis with Dynamically Similarity Guidance on Incomplete Data

Actuators
In actual industrial scenarios, collecting a complete dataset with all fault categories under the same conditions is challenging, leading to a loss in fault category knowledge in single-source domains.
Juan Tian, Shun Zhang, Gang Xie, Hui Shi
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Multi-source data-driven Bayesian network for risk analysis of maritime accidents in the high sea

Frontiers in Marine Science
Incomplete data significantly hampers risk analysis for high-sea maritime accidents (HSMAs). This paper introduces a novel multi-source data-driven Bayesian network (DDBN) framework to address this limitation.
Xiaotong Qu, Chengbo Wang, Chengbo Wang, Ruijia Zhao, Mingxing Fang, Mingxing Fang, Mingxing Fang, Xinlian Xie   +7 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A K-Means-Based Interpolation Algorithm With Lp-Norm and Feature Weighting

IEEE Access
The integrity of data is crucial for the majority of existing data analysis methods. However, incomplete and unbalanced datasets from the collection and organization process will affect analysis accuracy.
Yipeng Miao, Yenan Xu
doaj   +1 more source

Simulation analysis of an adjusted gravity model for hospital admissions robust to incomplete data. [PDF]

BMC Med Res Methodol, 2023
Latruwe T, Van der Wee M, Vanleenhove P, Michielsen K, Verbrugge S, Colle D.   +5 more
europepmc   +1 more source