Results 111 to 120 of about 2,499,784 (284)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Pseudo-Likelihood Estimation for Incomplete Data [PDF]

open access: yes, 2011
In statistical practice, incomplete measurement sequences are the rule rather than the exception. Fortunately, in a large variety of settings, the stochastic mechanism governing the incompleteness can be ignored without hampering inferences about the measurement process.
Molenberghs, Geert   +3 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Polyester Melt Characteristic Viscosity Prediction Method Under Incomplete Data

open access: yesShanghai Jiaotong Daxue xuebao
Characteristic viscosity is a key indicator of the quality of polyester melts, whose accurate prediction can help to identify potential quality problems of polyester melts in advance, adjust the process parameters in time and reduce enterprise losses ...
BI Jinmao, ZHANG Peng, ZHANG Jie, ZHAO Chuncai, CUI Li
doaj   +1 more source

Incomplete Data and Potential Risks of Drugs in People with Obesity. [PDF]

open access: yesCurr Obes Rep, 2023
Apovian CM   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Assessing data completeness in the international society for the study of pleura and peritoneum (ISSPP) PIPAC database: a multicenter evaluation from 2020–2024

open access: yesPleura and Peritoneum
In 2020, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) reached stage 2b of the IDEAL framework and a prospective international PIPAC database was launched in June 2020 by the International Society for the Study of the Pleura and Peritoneum ...
Jørgensen Magnus Skov   +20 more
doaj   +1 more source

Noisier2Inverse: Self-Supervised Learning for Image Reconstruction With Correlated Noise

open access: yesIEEE Access
We propose Noisier2Inverse, a correction-free, self-supervised deep learning method for general inverse problems. Our approach learns a reconstruction function without requiring ground truth data and is applicable in settings where measurement noise is ...
Nadja Gruber   +5 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Ambiguities, Built-In Biases, and Flaws in Big Data Insight Extraction

open access: yesInformation
I address the challenge of extracting reliable insights from large datasets using a simplified model that illustrates how hierarchical classification can distort outcomes. The model consists of discrete pixels labeled red, blue, or white.
Serge Galam
doaj   +1 more source

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