Results 241 to 250 of about 2,182,704 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

[Duration of incubation time in visceral leishmaniasis].

Meditsinskaia parazitologiia i parazitarnye bolezni, 2003
openaire   +1 more source

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Linkage of prion protein and scrapie incubation time genes

Cell, 1986
A single gene (Prn-i) that affects scrapie incubation period in mice has been identified. I/LnJ mice have a very long incubation period after inoculation of scrapie prions (200-385 days) and NZW/LacJ mice have a short one (113 +/- 2.8 days). (NZW X I/Ln)F1 hybrid mice had incubation times of 223 +/- 2.8 days indicating longer incubation times were ...
Carlson, G A, Kingsbury, D T, Goodman, P A, Coleman, S, Marshall, S T, DeArmond, S, Westaway, D, Prusiner, S B   +7 more
openaire   +4 more sources

Incubation time for AIDS from French transfusion-associated cases

Nature, 1989
Although incubation time is a key parameter of the epidemiology of AIDS, statistical estimates based on transfusion-associated AIDS cases have, up to now, used only the single dataset provided by the AIDS program of the Centers for Disease Control (CDC) in Atlanta.
D, Costagliola, J Y, Mary, N, Brouard, A, Laporte, A J, Valleron   +4 more
openaire   +4 more sources

INCUBATION TIME OF EPIDEMIC POLYARTHRITIS

Medical Journal of Australia, 1980
The incubation time of epidemic polyarthritis was estimated in 20 patients with evidence of Ross River virus infection after spending less than three weeks in areas of risk. The smallest estimate consistent with all cases was a range of seven to nine days.
J R, Fraser, A L, Cunningham
openaire   +2 more sources

Incubation time in reptilian eggs

Journal of Zoology, 1996
An allometric analysis of reptilian incubation time was performed. Incubation time increased with increasing egg mass (allometric exponent = 0.14, r2= 0.31). However, significant heterogeneity was found within the Reptilia for this character. If periods of developmental arrest are excluded the orders Crocodylia, Testudinata, and the suborder Serpentes ...
G. F. Birchard, D. Marcellini
openaire   +1 more source