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Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives
Molecules, 2018 Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. Diversely substituted indazole derivatives bear a variety of functional groups and display versatile biological activities; hence, they have gained ...
Shu-Guang Zhang +2 more
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(7E)-3-(4-Methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole
Molbank, 2020 Indazole derivatives are well known to have various pharmacological activities. We synthesized a novel derivative of indazole, namely (7E)-3-(4-methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole by condensation reaction ...
Hariyanti Hariyanti +3 more
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Methyl 1-(4-fluorobenzyl)-1H-indazole-3-carboxylate
IUCrData, 2023 The title compound, C16H13FN2O2, was synthesized by nucleophilic substitution of the indazole N—H hydrogen atom of methyl 1H-indazole-3-carboxylate with 1-(bromomethyl)-4-fluorobenzene. In the crystal, some hydrogen-bond-like interactions are observed.
Takahiro Doi, Takayuki Sakai
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Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives
Molecules, 2021 Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar +9 more
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Beilstein Journal of Organic Chemistry, 2021 The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient ...
Ryan M. Alam, John J. Keating
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Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug
Applied Sciences, 2020 A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches.
Jagan Mohana Rao Saketi +7 more
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Molecules, 2017 Indazole is considered a very important scaffold in medicinal chemistry. It is commonly found in compounds with diverse biological activities, e.g., antimicrobial and anti-inflammatory agents.
Jaime Pérez-Villanueva +11 more
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3-Isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione
Molbank, 2022 Here we describe the functionalization of lupulone natural compound in obtaining 3-isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione.
José Edmilson Ribeiro do Nascimento +3 more
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IUCrData, 2018 In the title compound, C14H11N3O2, the indazole portion is planar to within 0.022 (2) Å and subtends a dihedral angle of 65.87 (7)° with the pendant benzene ring.
Mohamed Mokhtar Mohamed Abdelahi +4 more
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In vivo and In vitro Anti-Inflammatory Activity of Indazole and Its Derivatives [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications.
Chakrapani Cheekavolu, M. Muniappan
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