Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives
Molecules, 2018 Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. Diversely substituted indazole derivatives bear a variety of functional groups and display versatile biological activities; hence, they have gained ...
Shuguang Zhang +2 more
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Synthesis, Characterization, Antimicrobial Activity and Molecular Modeling Studies of Novel Indazole-Benzimidazole Hybrids [PDF]
AntibioticsBackground/Objectives: In this work, a series of six new indazole-benzimidazole hybrids (M1–M6) were designed, synthesized, and fully characterized. The design of these compounds was based on the combination of two pharmacophoric units, indazole and ...
Redouane Er-raqioui +14 more
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Nitroreductase-triggered indazole formation [PDF]
Nature CommunicationsBiocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen +5 more
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Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: An insight to experimental, in-vitro biological potential and computational approaches [PDF]
Saudi Pharmaceutical JournalIn this study, a series of newly synthesized indazole-based thiadiazole hybrid derivatives (1–13) were successfully synthesized from indazole-based thiosemicarbazides starting from the 5-methyl-1H-indazole-3-carboxylic acid.
Sabeen Arshad +6 more
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Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives
Molecules, 2021 Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties.
Karen Rodríguez-Villar +9 more
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(7E)-3-(4-Methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole
Molbank, 2020 Indazole derivatives are well known to have various pharmacological activities. We synthesized a novel derivative of indazole, namely (7E)-3-(4-methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-4,5,6,7-tetrahydro-3aH-indazole by condensation reaction ...
Hariyanti Hariyanti +3 more
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Beilstein Journal of Organic Chemistry, 2021 The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient ...
Ryan M. Alam, John J. Keating
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Methyl 1-(4-fluorobenzyl)-1H-indazole-3-carboxylate
IUCrData, 2023 The title compound, C16H13FN2O2, was synthesized by nucleophilic substitution of the indazole N—H hydrogen atom of methyl 1H-indazole-3-carboxylate with 1-(bromomethyl)-4-fluorobenzene. In the crystal, some hydrogen-bond-like interactions are observed.
Takahiro Doi, Takayuki Sakai
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Recent Advances in Synthetic Strategies and Biological Properties of Indazole Scaffolds: A Review [PDF]
Topics in Current ChemistryS B Jonnalagadda +2 more
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Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug
Applied Sciences, 2020 A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches.
Jagan Mohana Rao Saketi +7 more
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