Results 41 to 50 of about 4,776 (179)

Identification and development of novel indazole derivatives as potent bacterial peptidoglycan synthesis inhibitors

International Journal of Mycobacteriology, 2018
Background: Tuberculosis is well-known airborne disease caused by Mycobacterium tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths caused by the disease worldwide.
Prasanthi Malapati, Vagolu Siva Krishna, Sriram Dharmarajan   +2 more
doaj   +1 more source

The monoamine oxidase inhibition properties of indazole derivatives

Results in Chemistry
The monoamine oxidase (MAO) enzymes are important catalysts of the metabolism of biogenic and dietary amines in the central and peripheral nervous systems.
Mohau G. Mashishi, Jacobus P. Petzer, Chantalle Crous, Anél Petzer   +3 more
doaj   +1 more source

1-Chloro-3-(6-nitro-1H-indazol-1-yl)propan-2-ol

IUCrData, 2017
In the title compound, C10H10ClN3O3, the side chain is oriented nearly perpendicular to the mean plane of the indazole ring system. In the crystal, complementary sets of O—H...N and C—H...O hydrogen bonds form chains of molecules stacked along the a-axis
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening.
Jian Liu, Yu Wen, Lina Gao, Liang Gao, Fengjun He, Jingxian Zhou, Junwei Wang, Rupeng Dai, Xiaojing Chen, Di Kang, Lihong Hu   +10 more
doaj   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives

Intelligent Pharmacy
Aim of the study was designed to synthesize and evaluate antibacterial activity of novel heterocyclic compounds, 3-methyl-1H-indazole derivatives. The heterocyclic compounds, 3-methyl-1H-indazole derivatives (1a-1d and 2a-2d) were synthesized; all of ...
Farrukh Shaikh, Muhammad Arif, Mohammad Khushtar, Md Nematullah, Md Azizur Rahman   +4 more
doaj   +1 more source

Mechanistic and Reactivity Insights into Diboron‐Mediated NN and NN Bond Scission

European Journal of Organic Chemistry, Volume 29, Issue 25, 4 July 2026.
This review highlights the emerging ability of diboron reagents to cleave both π‐bonded (N=N) and σ‐bonded (N—N) nitrogen–nitrogen linkages, integrating mechanistic understanding with recent synthetic applications. Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like
Raúl Valderrama‐Callejón, Inés Alonso, M. Belén Cid   +2 more
wiley   +1 more source

Crystal structure of 2-[(3aS,6R)-3,3,6-trimethyl-3,3a,4,5,6,7-hexahydro-2H-indazol-2-yl]thiazol-4(5H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, C13H19N3OS, is a new thiazolidin-4-one derivative prepared and isolated as the pure (3aS,6R)-diastereisomer from (R)-thiosemicarbazone pulegone. It crystallized with two independent molecules (A and B) in the asymmetric unit.
Abdellah N'ait Ousidi, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Jean-Claude Daran, Auhmani Abdelwahed   +5 more
doaj   +1 more source

Mining for Novel Tryptophanase A: Extremophilic Organisms Ardenticatena maritima and Haloarcula japonica as Alternatives to E. coli in the Synthesis of Tryptophan Analogues

ChemCatChem, Volume 18, Issue 14, 29 July 2026.
Novel extremophilic tryptophanases (TnaAs) are tested in the synthesis of L‐tryptophan analogues. This study compares a thermophilic and a halophilic TnaA with E. coli TnaA as benchmark, from both structural and catalytic perspectives, revealing enhanced stability, and a broader substrate scope for the new homologues.
Fatemeh Aziziyan, Evelyn Sgroi, Giulia Frati, Omar Ben Mariem, Ivano Eberini, Alessandra Tolomelli, Francesca Paradisi   +6 more
wiley   +1 more source

Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C22H18N2O4, the three fused rings of the pyrazolophthalazine moiety are coplanar (r.m.s. deviation = 0.027 Å). The cyclohexene ring fused to the pyrazolidine ring, so forming the indazolophthalazine unit, has a half-chair ...
Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Zouhair Bouaziz   +4 more
doaj   +1 more source