Results 41 to 50 of about 7,519 (213)

Pharmacological properties of indazole derivatives: Recent developments

, 2013
The chemistry of indazole and its N-oxide derivatives is very well-known. Indazole derivatives were extensively studied as bioactive compounds, such as anti-aggregatory and vasorelaxant activity by NO release and increase of cGMP levels and anticancer ...
Cerecetto, Hugo, González, Mercedes, Ochoa de Ocáriz Herrero, Carmen, Gerpe, Alejandra, Arán, Vicente J.   +4 more
core   +1 more source

New indazole-indolizine-triazine hybrid molecules with farnesyltransferase inhibitory activity

Results in Chemistry
A new series of indazole-indolizine-triazine hybrid molecules was obtained by [3 + 2] cycloaddition reaction between newly synthesized nitrogen ylides with indazole skeleton and previously reported dipolarophile 2‐ethynyl‐4,6‐dimethoxy‐1,3,5‐triazine and
Liliana Ciurlă-Lucescu, Elena Bîcu, Dalila Belei, Alina Ghinet   +3 more
doaj   +1 more source

Redox‐Tuned Oxycarbamates Enable Divergent C─N and C─C Functionalization of Indolizines Under Photoredox Catalysis With Green Light

Chemistry – A European Journal, EarlyView.
Nonafluoromesitylsulfonyl (Nms)‐substituted oxycarbamates are introduced as redox‐lowered radical precursors for green‐light photoredox synthesis. Selective N─O bond cleavage generates amidyl radicals that directly aminate indolizines in DMF, whereas DMSO promotes 1,2‐hydrogen atom transfer (HAT) to α‐amino carbon‐centered radicals and C─C bond ...
Kevin Klaus Stefanoni, René Wilhelm
wiley   +1 more source

“On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole

Molecules, 2020
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3 ...
Khadija Gambouz, Abdelmoula El Abbouchi, Sarah Nassiri, Franck Suzenet, Mostapha Bousmina, Mohamed Akssira, Gérald Guillaumet, Saïd El Kazzouli   +7 more
doaj   +1 more source

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source

Investigation into the synthesis of Indazole [PDF]

, 1952
These investigations were undertaken in order to study the effect that various acyl or aroyl groups on o-toluidine have on the yield of indazole, when the latter is prepared by the methods of Barclay, et. al. (1) as modified by Rzeszotarski (23).
Dreyfuss, Max Peter
core  

1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis

, 2016
Antiapoptotic agents based on 1-benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock.
Fang-Yu Lee (3012330), Shiow-Lin Pan (137778), Jih-Hwa Guh (515083), Jin-Cherng Lien (3012339), Sheng-Chu Kuo (416362), Li-Jiau Huang (2248612), Che-Ming Teng (137773)   +6 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Isomeric [RuCl2(dmso)2(indazole)2] complexes: Ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole

, 2005
Reaction of the antitumor complex trans-[RuIIICl 4(Hind)2]- (Hind = indazole) with an excess of dimethyl sulfoxide (dmso) in acetone afforded the complex trans,trans,trans- [RuIICl2(dmso)2(Hind)2] (1).
Arion, V., Reisner, Erwin, Chiorescu, I., Keppler, Bernhard K., Reisner, E., Arion, Vladimir B., Schmid, W., Schmid, Wolfgang F., Rufinska, A., Rufińska, Anna, Keppler, B., Chiorescu, Ion   +11 more
core   +1 more source

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source