Results 51 to 60 of about 4,776 (179)

Abuse Potential and Neurotoxic Effects of the Synthetic Cannabinoid 4F‐ABUTINACA Self‐Administration in Adult Male Rats

Addiction Biology, Volume 31, Issue 7, July 2026.
4F ABUTINACA maintains stable intravenous self‐administration at low doses in male rats, supporting its high abuse potential. Chronic exposure to 4F‐ABUTINACA induces persistent anxiety‐like behaviors and is associated with region‐specific neurotoxicity in the hippocampus, prefrontal cortex and nucleus accumbens, alongside dysregulation of the BDNF ...
Baobao Shi, Huizhen Liu, Manqing Wu, Yuting Wang, Dan Fu, Lili Wen, Huifen Liu, Peng Xu, Wenhua Zhou, Haitao Wang, Miaojun Lai   +10 more
wiley   +1 more source

New azo disperse dyes containing cyclohexanone ring for dyeing polyester and nylon fabrics

Macedonian Journal of Chemistry and Chemical Engineering, 2010
Condensation of 2,4-diacarboethoxy-5-hydroxy-3-(4-methoxyphenyl)-5-methyl cyclohexanone (1) with equimolar amounts of hydrazine hydrate and phenyl hydrazine afforded the corresponding 2H-indazole-5-carboxylates 2a and 2b, respectively.
Hatem E. Gaffer, Mohamed A. E. Khalifa, Shaima F. El-Bially, Mohamed A. Metwally   +3 more
doaj   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Synthesis, Characterization, In-silico and Biological Evaluation of Indazole Derivatives as Potential Anti-Inflammatory and Antimicrobial Agents

RGUHS Journal of Pharmaceutical Sciences
Introduction Indazoles also known as isoindazone or benzpyrazole are fused bicyclic heteroaromatic organic molecules with a wide range of biological activities.
Hanamant B Sannakki, Somashekhar Metri, Amit Mandave, Trupti A Hunnura, Pratik M, Vishal Babar, Mahesh AR   +6 more
doaj   +1 more source

2,2′-(Propane-1,3-diyl)bis(2H-indazole)

Acta Crystallographica Section E, 2011
The title molecule, C17H16N4, is a bis-indazole crystallized in the rare 2H-tautomeric form. Indazole heterocycles are connected by a propane C3 chain, and the molecule is placed on a general position, in contrast to the analogous compound with a central
Saúl Ovalle, Sylvain Bernès, Nancy Pérez Rodríguez, Perla Elizondo Martínez   +3 more
doaj   +1 more source

Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives

Scientific Reports
The BraSR two-component system plays a crucial role in bacitracin sensing and resistance in Staphylococcus aureus, making the BraS histidine kinase an attractive antibacterial target. In this study, we applied a structure-based drug discovery approach to
Grijesh Jaiswal, Sandesh Telang, Tripti Shrivastava, Shantu Amin, Arun K. Sharma, Krishne Gowda, Sandeep Kumar Srivastava   +6 more
doaj   +1 more source

1-(4-Methylphenylsulfonyl)-5,6-dinitro-1H-indazole

Acta Crystallographica Section E, 2014
In the title compound, C14H10N4O6S, the indazole ring system is almost perpendicular to the tosyl ring, as indicated by the dihedral angle of 89.40 (9)° between their planes.
Bassou Oulemda, El Mostapha Rakib, Najat Abbassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

Chemistry
New EA-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{1H and 13C}, infrared ...
Nassima Saghdani, Nabil El Brahmi, Abdelmoula El Abbouchi, Rachid Haloui, Souad Elkhattabi, Gérald Guillaumet, Saïd El Kazzouli   +6 more
doaj   +1 more source

Indazole: Photoleitfähigkeit und Oxidationspotentiale

CHIMIA, 1988
In sensitized electrophotographic layers, excellent charge transport properties are exhibited by 2-(p-aminophenyl)indazoles (1). Corresponding 2-aminoindazoles (2) are ineffective.
Bernhard Albert, Peter Neumann, Gerhard Hoffmann   +2 more
doaj   +1 more source