Results 51 to 60 of about 7,519 (213)

Synthesis of substituted 3-amino-N-phenyl-1H-indazole-1-carboxamides endowed with antiproliferative activity

, 2011
Several new N-phenyl-1H-indazole-1-carboxamides 1c–h and 4l,m were prepared by reacting phenyl isocyanate derivatives 3a,b with 3-amino-1H-indazole derivatives 2c,e,g or 1H-indazole 2l respectively.
Rosaria Maria Pipitone, RAIMONDI, Maria Valeria, PLESCIA, Fabiana, CASCIOFERRO, Stella Maria, MAGGIO, Benedetta, Salvatore Plescia, Maria Valeria Raimondi, Manlio Tolomeo, RAFFA, Demetrio, Stella Cascioferro, DI CRISTINA, Antonietta, Benedetta Maggio, Antonietta Di Cristina, DAIDONE, Giuseppe, Giuseppe Daidone, PIPITONE, Rosaria Maria, PLESCIA, Salvatore, GRIMAUDO, Stefania, Fabiana Plescia, Tolomeo, M, Demetrio Raffa, Stefania Grimaudo   +21 more
core   +1 more source

1-(4-Methylphenylsulfonyl)-5,6-dinitro-1H-indazole

Acta Crystallographica Section E, 2014
In the title compound, C14H10N4O6S, the indazole ring system is almost perpendicular to the tosyl ring, as indicated by the dihedral angle of 89.40 (9)° between their planes.
Bassou Oulemda, El Mostapha Rakib, Najat Abbassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Cis–Trans Rotational Isomerism of Formic Acid, Sulfur, and Selenium Analogues and Their Dimers: Chemical Kinetics Under Interstellar Conditions

International Journal of Chemical Kinetics, Volume 58, Issue 12, Page 1136-1145, December 2026.
ABSTRACT We present chemical kinetic rate constants for the cis to trans isomerisation or rotamerization of monomeric seleno‐, thio‐, and formic acids and that of three of their dimeric species, based on variational transition state theory and multidimensional tunneling calculations in the gas‐phase, from 10 K to 300 K. These provide, firstly, reliable
Judith Wurmel, John M. Simmie
wiley   +1 more source

Formation of Indazole Derivatives from 2,4-Disubstituted Thiosemicarbazides and some Chloro-p-Quinones

, 2010
The reaction of 2,4-disubstituted thiosemicarbazides with 2,3,5,6-tetrachloro-1,4-benzo-quinone gave 2-aryl-5,6-dichloro-3-(substituted imino)-2,3-dihydro-1 H-indazole-4,7-diones in 57–66% yield together with smaller amounts of 2-aryl-3-(substituted ...
Mamdouh A. Mohamed, Ashraf A. Aly, Alaa A. Hassan   +2 more
core   +1 more source

Discrete and polymeric Cu(II) complexes featuring substituted indazole ligands: their synthesis and structural chemistry [PDF]

, 2014
Reported here are the syntheses of four indazole-based ligands and the structural characterisation of four Cu(II) complexes derived from them. The ligands 1-(2-pyridyl)-1H-indazole, L1, and 2-(2-pyridyl)-2Hindazole, L2, have been characterised by ...
Hawes, C.S., Hawes, Chris S., Kruger, P.E., Kruger, Paul E.   +3 more
core   +1 more source

The monoamine oxidase inhibition properties of indazole derivatives

Results in Chemistry
The monoamine oxidase (MAO) enzymes are important catalysts of the metabolism of biogenic and dietary amines in the central and peripheral nervous systems.
Mohau G. Mashishi, Jacobus P. Petzer, Chantalle Crous, Anél Petzer   +3 more
doaj   +1 more source

A Tale of Two Heterocycles: How Oxygen and Sulfur Shape Divergent Kemp Reactivity

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
Like benzisoxazoles, benzisothiazoles also undergo Kemp elimination, with rates accelerated by aprotic polar solvents and electron‐withdrawing groups. Oxygen‐containing heterocycles exhibit more localized negative charges than sulfur analogs, resulting in a more pronounced catalytic response to these environmental factors. ABSTRACT The Kemp elimination
Ella R. Jennings, Hannah S. Todd, Emilie Perelman, Courtney B. Limehouse, Hunter J. Savage, Marcello Forconi   +5 more
wiley   +1 more source

Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives

Intelligent Pharmacy
Aim of the study was designed to synthesize and evaluate antibacterial activity of novel heterocyclic compounds, 3-methyl-1H-indazole derivatives. The heterocyclic compounds, 3-methyl-1H-indazole derivatives (1a-1d and 2a-2d) were synthesized; all of ...
Farrukh Shaikh, Muhammad Arif, Mohammad Khushtar, Md Nematullah, Md Azizur Rahman   +4 more
doaj   +1 more source

Ethyl 2-(6-nitro-1H-indazol-1-yl)acetate

IUCrData, 2017
The asymmetric unit of the title compound, C11H11N3O4, comprises two independent molecules, both of which display positional disorder of their ethyl chains in 0.868 (4):0.132 (4) and 0.839 (4):0.161 (4) ratios. The packing is directed by a combination of
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source