Results 61 to 70 of about 7,519 (213)

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Identification and development of novel indazole derivatives as potent bacterial peptidoglycan synthesis inhibitors

International Journal of Mycobacteriology, 2018
Background: Tuberculosis is well-known airborne disease caused by Mycobacterium tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths caused by the disease worldwide.
Prasanthi Malapati, Vagolu Siva Krishna, Sriram Dharmarajan   +2 more
doaj   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

1-Chloro-3-(6-nitro-1H-indazol-1-yl)propan-2-ol

IUCrData, 2017
In the title compound, C10H10ClN3O3, the side chain is oriented nearly perpendicular to the mean plane of the indazole ring system. In the crystal, complementary sets of O—H...N and C—H...O hydrogen bonds form chains of molecules stacked along the a-axis
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Recent Advances in Chemosensors Bearing Pyrazole and Imidazole Rings: An Approach Toward the Detection of Metal Ions Based on these Diazoles

Advanced Sensor Research, Volume 5, Issue 10, October 2026.
This contribution analyzes recent articles (2021–2025) on chemosensors containing pyrazole and imidazole rings for detecting metal ions, using distinctive examples. It focuses on the structural design of probes, their coordination behavior, sensing mechanisms, and analytical performance, including selectivity, sensitivity, working wavelength, and ...
Alexander Ladino‐Bejarano, Carlos Cifuentes, Néstor Bravo, Jaime Portilla   +3 more
wiley   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source

Electronic Spectra of Hydrogen-Bonded Indazole in a Supersonic Free Jet [PDF]

, 2003
Fluorescence properties of indazole complexes with various protic molecules in supersonic jets are investigated. Indazole forms hydrogen-bonded complexes with acetic acid, formic acid, water and ethanol in jets and the 0-0 bands are shifted by 256, 243 ...
6101, Noda-Terazima, Masayo
core  

Machine Learning for Synthetic Organic Chemistry: Methods, Applications, and Best Practices

Angewandte Chemie Novit, Volume 2, Issue 3, September 2026.
Artificial intelligence (AI) and machine learning (ML) are increasingly reshaping experimental chemistry. This review maps the challenges of synthetic organic chemistry to modern digital tools that can help address them. While focusing on the practical application of ML tools in real‐world laboratory settings, we outline prerequisites, emerging ...
Niklas Hölter, Felix Katzenburg, Florian Boser, Frank Glorius   +3 more
wiley   +1 more source

Metal-Free Synthesis of 2H‑Indazole Skeletons by Photochemistry or Thermochemistry

, 2023
A simple and tuned synthesis of a 2H-indazole skeleton under metal-free conditions was developed. Under visible-light irradiation at room temperature, 2-((aryl/alkyl/H)ethynyl))aryltriazenes reacted with arylsulfinic acids to afford 3-functionalized 2H ...
Pinhua Li (1457875), Yicheng Zhang, Gan Zhang (334914), Lei Wang (6656), Yicheng Zhang (790286), Lei Wang, Chao Zhou, Chao Zhou (471522), Min Wang, Gan Zhang, Min Wang (21070), Pinhua Li   +11 more
core   +1 more source

Synthesis, Characterization, In-silico and Biological Evaluation of Indazole Derivatives as Potential Anti-Inflammatory and Antimicrobial Agents

RGUHS Journal of Pharmaceutical Sciences
Introduction Indazoles also known as isoindazone or benzpyrazole are fused bicyclic heteroaromatic organic molecules with a wide range of biological activities.
Hanamant B Sannakki, Somashekhar Metri, Amit Mandave, Trupti A Hunnura, Pratik M, Vishal Babar, Mahesh AR   +6 more
doaj   +1 more source