Results 31 to 40 of about 7,519 (213)

Palladium‐Catalyzed Cross‐Coupling of Transiently Stable Heterocyclic Organolithiums

Angewandte Chemie International Edition, EarlyView.
Fast coupling outcompetes organolithium decomposition. Catalyst benchmarking enables transient pyridyl, quinolyl, indazolyl, and related organolithiums to participate in the Murahashi coupling, while continuous‐flow generation extends the approach to reagents too unstable for conventional batch handling.
Piyas Saha, Francisco José Aguilar Troyano, Soumitra Ghosh, Stephen G. Newman   +3 more
wiley   +1 more source

Reactions in the Synthesis of Indazole [PDF]

, 1954
This investigation was undertaken to study the reaction mechanism involved in the formation of Indazole. A study was also made to determine the effect of a polar solvent on the yield of Indazole using Dreyfuss\u27 method of ...
Webb, Richard Velmer
core  

Recent Advances in Indazole-Derived Heterocycles: Synthetic Strategies, Functionalization, and Therapeutic Potential

Journal of Chemistry
Indazole-derived heterocycles have garnered significant attention in recent years due to their versatile chemical structures and wide-ranging biological activities. This review explores the recent progress in the synthesis of indazole-based heterocycles,
Uday V. Bhat, Glanish Jude Martis, Dinesh Chikkanna, Santosh L. Gaonkar   +3 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors

Molecules, 2016
Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5 ...
Zhen Zhang, Dongmei Zhao, Yang Dai, Maosheng Cheng, Meiyu Geng, Jingkang Shen, Yuchi Ma, Jing Ai, Bing Xiong   +8 more
doaj   +1 more source

Indazole carboxylic acids in male contraception

, 2002
Two new chemical entities, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide and 1-(2,4-dichlorobenzyl)-indazole-3-acrylic acid, were synthesized based on the core structure of lonidamine (1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid).
CHENG CY, TITA B, SASO, Luciano, SILVESTRINI, Bruno, MO M, GRIMA J, MRUK D, C.Yan Cheng, Dolores Mruk, Bruno Silvestrini, Josephine Grima, Meng-yun Mo, Luciano Saso, Beatrice Tita   +13 more
core   +1 more source

Regioselective alkylation of a versatile indazole: Electrophile scope and mechanistic insights from density functional theory calculations

Beilstein Journal of Organic Chemistry
Herein, we report a pair of regioselective N1- and N2-alkylations of a versatile indazole, methyl 5-bromo-1H-indazole-3-carboxylate (6) and the use of density functional theory (DFT) to evaluate their mechanisms. Over thirty N1- and N2-alkylated products
Pengcheng Lu, Luis Juarez, Paul A. Wiget, Weihe Zhang, Krishnan Raman, Pravin L. Kotian   +5 more
doaj   +1 more source

Ethyl 3-[6-(4-methoxybenzenesulfonamido)-2H-indazol-2-yl]propanoate monohydrate

Acta Crystallographica Section E, 2013
In the title compound, C19H21N3O5S·H2O, the central indazole system is essentially planar (r.m.s. deviation = 0.012 Å), while both the benzene ring and the mean plane defined by the non-H atoms of the ethyl propionic ester unit (r.m.s ...
Najat Abbassi, El Mostapha Rakib, Abdellah Hannioui, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Modulating spin dynamics of binuclear Ln^III–radical complexes by using different indazole radicals

, 2017
Four LnIII–indazole–radical complexes have been synthesized. By changing the location of the radical in the indazole ring, they exhibit interesting magnetic properties.
Feng Zhen Hua, Li Tian, Xiu Juan Shi, Si Jia Yu, Yuan Yuan Xu, Ting Li, Zhong Yi Liu, Peng Yun Chen   +7 more
core   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source