Exploring Novel Indazole and Pyrazole Nucleoside Analogues: Enzymatic Synthesis, Characterization, and Biological Evaluation. [PDF]
Int J Mol SciNew indazole and pyrazole nucleoside analogues were synthesized by enzymatic transglycosylation using E. coli purine nucleoside phosphorylase (PNP). Indazoles substituted at position 5 or 6 with bromine, pyrazole or pyrimidine fragments were used as ...
Mironov AF +13 more
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Intelligent Pharmacy, 2023 Indazole is a very significant group of heterocyclics. Aim of the research was thus planned to synthesize novel derivatives of indazole and evaluate their anti-inflammatory activity.
Vishal Kumar +4 more
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Beilstein Journal of Organic Chemistry, 2016 A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis.
Manjunatha Narayanarao +4 more
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Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives [PDF]
Scientific ReportsThe BraSR two-component system plays a crucial role in bacitracin sensing and resistance in Staphylococcus aureus, making the BraS histidine kinase an attractive antibacterial target. In this study, we applied a structure-based drug discovery approach to
Grijesh Jaiswal +6 more
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Synthesis, Characterization, Antimicrobial Activity and Molecular Modeling Studies of Novel Indazole-Benzimidazole Hybrids [PDF]
AntibioticsBackground/Objectives: In this work, a series of six new indazole-benzimidazole hybrids (M1–M6) were designed, synthesized, and fully characterized. The design of these compounds was based on the combination of two pharmacophoric units, indazole and ...
Redouane Er-raqioui +14 more
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Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives [PDF]
Molecules, 2016 A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor.
Efrain Polo +5 more
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2,2′-(Propane-1,3-diyl)bis(2H-indazole) [PDF]
Acta Crystallographica Section E, 2011 The title molecule, C17H16N4, is a bis-indazole crystallized in the rare 2H-tautomeric form. Indazole heterocycles are connected by a propane C3 chain, and the molecule is placed on a general position, in contrast to the analogous compound with a central
Saúl Ovalle +3 more
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Nitroreductase-triggered indazole formation [PDF]
Nature CommunicationsBiocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen +5 more
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Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: An insight to experimental, in-vitro biological potential and computational approaches [PDF]
Saudi Pharmaceutical JournalIn this study, a series of newly synthesized indazole-based thiadiazole hybrid derivatives (1–13) were successfully synthesized from indazole-based thiosemicarbazides starting from the 5-methyl-1H-indazole-3-carboxylic acid.
Sabeen Arshad +6 more
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, 2022 The article deals with the newer classes of mononuclear: [(acac)2RuIII(H-Iz)(Iz–)] 1, [(acac)2RuIII(H-Iz)2]ClO4 [1]ClO4/[1′]ClO4, and [(bpy)2RuII(H-Iz)(Iz–)]ClO4 [2]ClO4, mixed-valent unsymmetric dinuclear: [(acac)2RuIII(μ-Iz–)2RuII(bpy)2]ClO4 [3]ClO4 ...
Maya Kumari (13850435) +3 more
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