Results 11 to 20 of about 4,776 (179)

Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2. [PDF]

ChemMedChem
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Amoussa M, Efrém NL, Li F, Guo Z, Roske Y, Frank KJ, Pach S, Wolf CA, Bo F, Lesina M, Kintzel M, Alsalim R, Zeitz V, Csorba N, Radetzki S, Keserű GM, Daumke O, Algül H, Wolber G, Li J, Nazaré M.   +20 more
europepmc   +2 more sources

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents

Molecules, 2017
Indazole is considered a very important scaffold in medicinal chemistry. It is commonly found in compounds with diverse biological activities, e.g., antimicrobial and anti-inflammatory agents.
Jaime Pérez-Villanueva, Lilián Yépez-Mulia, Ignacio González-Sánchez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche, Teresita del Rosario Sainz-Espuñes, Marco A. Cerbón, Karen Rodríguez-Villar, Ana Karina Rodríguez-Vicente, Miguel Cortés-Gines, Zeltzin Custodio-Galván, Dante B. Estrada-Castro   +11 more
doaj   +1 more source

2-Benzyl-6-nitro-2H-indazole

IUCrData, 2018
In the title compound, C14H11N3O2, the indazole portion is planar to within 0.022 (2) Å and subtends a dihedral angle of 65.87 (7)° with the pendant benzene ring.
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2H-indazole Hybrids

Pharmaceuticals, 2021
Cancer is the second leading cause of death, after cardiovascular diseases. Different strategies have been developed to treat cancer; however, chemotherapy with cytotoxic agents is still the most widely used treatment approach.
Jaime Pérez-Villanueva, Félix Matadamas-Martínez, Lilián Yépez-Mulia, Vadim Pérez-Koldenkova, Martha Leyte-Lugo, Karen Rodríguez-Villar, Francisco Cortés-Benítez, Ana Perla Macías-Jiménez, Ignacio González-Sánchez, Ariana Romero-Velásquez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche   +11 more
doaj   +1 more source

Synthesis of indazolo[5,4-b][1,6]naphthyridine and indazolo[6,7-b][1,6]naphthyridine derivatives

Heterocyclic Communications, 2019
A simple method for the synthesis of the title compounds by an efficient in-situ reduction and cyclization reactions of aromatic aldehydes, tert-butyl 2,4-dioxopiperidine-1-carboxylate and 5-nitro-1H-indazole or 6-nitro-1H-indazole was developed.
Chen Dong-Mei, Liu Jia-Yan, Wei Ming, Wang Bing-Wei, Chu Ruo-Han, Chen Dong-Sheng   +5 more
doaj   +1 more source

In vivo and In vitro Anti-Inflammatory Activity of Indazole and Its Derivatives [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications.
Chakrapani Cheekavolu, M. Muniappan
doaj   +1 more source

Synthesis of 1,3-substituted 1H-indazole derivatives and evaluation of anti-inflammatory activity in Sprague Dawley rats

Intelligent Pharmacy
Indazole is a very significant group of heterocyclics. Aim of the research was thus planned to synthesize novel derivatives of indazole and evaluate their anti-inflammatory activity.
Vishal Kumar, Anup Kumar Sirbaiya, Md Nematullah, Md Faheem Haider, Md Azizur Rahman   +4 more
doaj   +1 more source

Tris[2-(2H-indazol-2-yl)ethyl]amine

Acta Crystallographica Section E, 2012
The title tertiary amine, C27H27N7, a potential tripodal ligand for coordination chemistry, crystallizes with the central N atom located on a threefold axis of a trigonal cell. The gauche conformation of the N(amime)—CH2—CH2—
Saúl Ovalle, Perla Elizondo Martínez, Nancy Pérez Rodríguez, Sylvain Bernès, Marcos Flores-Alamo   +4 more
doaj   +1 more source

Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives

Molecules, 2016
A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor.
Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdámez, Jairo Quiroga, Margarita Gutierrez   +5 more
doaj   +1 more source

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

Beilstein Journal of Organic Chemistry, 2016
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis.
Manjunatha Narayanarao, Lokesh Koodlur, Vijayakumar G. Revanasiddappa, Subramanya Gopal, Susmita Kamila   +4 more
doaj   +1 more source