Results 91 to 100 of about 4,056 (217)
MolbankIndazoles are a very important group of nitrogen-containing heterocycles with a wide range of biological and medicinal applications. These properties make them highly attractive for drug development, particularly when combined with sulfonamides to ...
Nassima Saghdani +3 more
doaj +1 more source
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-CARBETHOXY-5-(3'-BROMOPHENYL)-3-ARYL-2-CYCLOHEXENONES AND 6-ARYL-4-(3'-BROMOPHENYL)-3-OXO-2,3A,4,5-TETRAHYDRO-2H-INDAZOLES [PDF]
Journal of Sciences, Islamic Republic of Iran, 2002 6-Carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-Aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by Micheal addition of ethyl acetoacetate, followed by internal Claisen condensation.
doaj
Interaction of Bioactive Pyrazolo[4,3-a]acridines with Human Serum Albumin [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2017 Several heterocyclic bioactive fluorescent 3-alkyl-3H-pyrazolo[4,3-a]acridin-11-carbonitriles were conveniently synthesized from the reaction of 1-alkyl-1H-indazoles with different aryl acetonitrile in basic methanol solution in good yields.
Fatemeh Khosravi +2 more
doaj
Synthesis, In Vitro and In Silico Antibacterial Evaluation of 4,5-Dihydro-1H -Indazoles
, 2017 Synthesis and evaluation of in-vitro and in-silico anti-bacterial potential of a series of 4, 5-dihydro-1H-indazoles is reported here. The synthesis of the target 4,5-dihydro-1H-indazoles was accomplished by reacting 1,5-diaryl,4-acetyl cyclohexen-3-one ...
Faiza Shah +10 more
core +1 more source
, 2020 Copyright © 2020 American Chemical Society. C3-substituted 1H-indazoles are useful and important substructures in many pharmaceuticals. Methods for direct C3-functionalization of indazoles are relatively rare, compared to reactions developed for the more
Kevlishvili, Ilia +6 more
core +1 more source
, 2010 A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)-C(3) disubstituted indazoles in moderate to excellent ...
Moses, J. E. +5 more
core +1 more source
Synthesis of 1H‑Indazoles and 1H‑Pyrazoles via FeBr3/O2 Mediated Intramolecular C–H Amination
, 2016 A new synthesis of substituted 1H-indazoles and 1H-pyrazoles from arylhydrazones via FeBr3/O2 mediated C–H activation/C–N bond formation reactions is reported.
Tianshui Zhang (1923307) +1 more
core +1 more source
A general one-pot synthesis of 2H-indazoles using an organophosphorus-silane system
, 2018 A simple and direct approach for the regioselective construction of the privileged 2H‐indazole scaffold is described. The developed one‐pot strategy involves phospholene‐mediated N−N bond formation to access 2H‐indazoles.
Marc Nazaré +9 more
core +1 more source
Palladium-Catalyzed Direct C7-Arylation of Substituted Indazoles
, 2016 A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave
Mohammed Naas (1662133) +4 more
core +1 more source