Results 81 to 90 of about 4,056 (217)

Visible-Light-Driven Decarboxylative Coupling of 2H‑Indazoles with α‑Keto Acids without Photocatalysts and Oxidants

An efficient synthesis of functionalized 3-acyl-2H-indazoles via visible-light-induced self-catalyzed energy transfer was developed. This method utilized a self-catalyzed energy transfer process between 2H-indazoles and α-keto acids, offering advantages ...
Chen Yang (207381), Zhenlu Shen (2320999), Mingzhu Leng (18417203), Meichao Li (9277064), Mengyu Niu (9400131), Qun Cao (9304116)   +5 more
core   +3 more sources

New Synthesis of 1-Substituted-1H-indazoles via 1,3-Dipolar Cycloaddition of in situ Generated Nitrile Imines and Benzyne

, 2016
A new synthesis of 1-substitued-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)−C(3) disubstituted indazoles in moderate to excellent ...
Steve Keeling (2278165), Christian Spiteri (2202430), John E. Moses (2020789)   +2 more
core   +1 more source

Metal-Free Trifluoromethylation of Indazoles

, 2018
A simple and efficient tert-butyl hydroperoxide-mediated direct trifluoromethylation of indazoles using sodium trifluoromethanesulfinate has been developed under metal-free conditions.
Alakananda Hajra (1600114), Payel Ghosh (5877212), Susmita Mondal (174649)   +2 more
core   +2 more sources

Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach

, 2019
An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This “anion pool” approach electrochemically reduces indazole molecules generating indazole anions and H2.
Aaron K. Vannucci (1602109), D. M. M. Mevan Dissanayake (4679074)   +1 more
core   +1 more source

One-pot access to indazole fused-phenanthridinones via Rh(III)-catalyzed [4+2] annulation

Green Synthesis and Catalysis
An efficient synthesis of indazole fused phenanthridinones via Rh(III)-catalyzed inert C(sp2)-H activation/[4 ​+ ​2] annulation of 3-aryl-1H-indazoles with iodonium ylides has been developed, providing a strategy to access multi-conjugated π-system ...
Shumin Li, Jinke Chang, Jian Shen, Xiuling Cui   +3 more
doaj   +1 more source

Synthesis of Substituted 1H-Indazoles from Arynes and Hydrazones

, 2016
The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles.
Feng Shi (305643), Jingjing Zhao (129177), Pan Li (335711), Donald C. Rogness (2095807), Chunrui Wu (1848925)   +4 more
core   +1 more source

Preparation and catalytic study on a novel amino-functionalized silica-coated cobalt oxide nanocomposite for the synthesis of some indazoles

Acta Chimica Slovenica, 2017
In this research an efficient synthesis of a novel nanocomposite including SiO2@(3-aminopropyl)triethoxysilane-coated cobalt oxide (Co3O4) nanocomposite has been reported by three step method. The structure and magnetic characterization of Co3O4@SiO2@NH2
Mohammad Ali Ghasemzadeh, Bahar Molaei, Mohammad Hossein Abdollahi-Basir, Farzad Zamani   +3 more
doaj   +1 more source

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–H ...
Jonathan Elie, Johnny Vercouillie, Nicolas Arlicot, Lucas Lemaire, Rudy Bidault, Sylvie Bodard, Christel Hosselet, Jean-Bernard Deloye, Sylvie Chalon, Patrick Emond, Denis Guilloteau, Frédéric Buron, Sylvain Routier   +12 more
doaj   +1 more source

Synthesis of new indazoles derivatives with therapeutic potential

, 2016
L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles.
Naas, Mohammed
core  

Regioselective Synthesis of 2H‑Indazoles Using a Mild, One-Pot Condensation–Cadogan Reductive Cyclization

, 2016
An operationally simple and efficient one-pot synthesis of 2H-indazoles from commercially available reagents is reported. Ortho-imino-nitrobenzene substrates, generated via condensation, undergo reductive cyclization promoted by tri-n-butylphosophine to ...
Liuqing Wei (839643), Gary E. Aspnes (1796362), Nathan E. Genung (1796365)   +2 more
core   +1 more source