Results 61 to 70 of about 4,056 (217)
, 2014 Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported.
Farber K.M. +11 more
core +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
The Expanding Role of Diazirines in Synthetic Methodology
European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic +3 more
wiley +1 more source
Theoretical estimation of the annular tautomerism of indazoles
, 2013 Theoretical calculations at semi-empirical AM1 and density functional B3LYP/6-31G* levels were carried out on 52 NH-indazoles. Although in most cases the 1H-tautomer is the most stable, we found several indazoles for which the 2H-tautomer is more stable ...
Elguero, José, Alkorta, Ibon
core +1 more source
Photo- and electro-chemical strategies for indazole synthesis
Tetrahedron ChemThe indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential in medicinal chemistry and drug discovery, which therefore has attracted sustained attention from the synthetic community.
Binbin Huang
doaj +1 more source
Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
CHIMIA, 2003 Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers.
Peter Schäfer +4 more
doaj +1 more source
Advanced Sensor Research, Volume 5, Issue 10, October 2026.This contribution analyzes recent articles (2021–2025) on chemosensors containing pyrazole and imidazole rings for detecting metal ions, using distinctive examples. It focuses on the structural design of probes, their coordination behavior, sensing mechanisms, and analytical performance, including selectivity, sensitivity, working wavelength, and ...
Alexander Ladino‐Bejarano +3 more
wiley +1 more source
A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery
Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih +6 more
wiley +1 more source
Synthesis of 2H-Indazoles by the [3 + 2] Dipolar Cycloaddition of Sydnones with Arynes
, 2016 A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed ...
Feng Shi (305643) +3 more
core +1 more source
1H-Indazoles as Synthetic Auxiliaries for the Synthesis of Secondary Aromatic Amines.
, 1994 Methodology of alkylation of aromatic amines using 1H-indazoles as synthetic auxiliaries is ...
Nicoletti, R. +2 more
core +2 more sources