Results 41 to 50 of about 4,056 (217)
Química Nova, 2010 The synthesis and reactivity of α-oxoketenes dithioacetals (S,S-acetals), general structure [(R¹C=OC(R²)=C(SR³)(SR4)], are reported. We also showed the application of S,S acetals as synthons for efficient synthesis of isoxazoles, pyrazoles ...
Geonir M. Siqueira +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen +7 more
wiley +1 more source
, 2018 A direct acyl radical addition to 2H-indazoles has been achieved for the first time, where the less-aromatic quinonoid 2H-indazoles readily accepted radical species to the C-3 position. Motivated by the lack of direct acylation strategy for 2H-indazoles,
Ganganna Bogonda (5123009) +2 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Multitarget drugs are a promising therapeutic approach against Alzheimer’s disease. In this work, a new family of 5-substituted indazole derivatives with a multitarget profile including cholinesterase and BACE1 inhibition is described.
Pedro González-Naranjo +9 more
doaj +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. [PDF]
, 2012 The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good ...
Unsinn, Andreas, Knochel, Paul
core +1 more source
Chemistry – A European Journal, EarlyView.Nonafluoromesitylsulfonyl (Nms)‐substituted oxycarbamates are introduced as redox‐lowered radical precursors for green‐light photoredox synthesis. Selective N─O bond cleavage generates amidyl radicals that directly aminate indolizines in DMF, whereas DMSO promotes 1,2‐hydrogen atom transfer (HAT) to α‐amino carbon‐centered radicals and C─C bond ...
Kevin Klaus Stefanoni, René Wilhelm
wiley +1 more source
, 2009 Reaction of indazoles with aldehydes in the presence of p-toluenesulfinic acid affords the corresponding sulfonyl indazoles in satisfactory yields. The reported Friedel-Crafts process is rather unusual on indazoles because of the reduced electronic ...
S. CAMPETELLA +5 more
core +1 more source
Molecules, 2018 Herein we report an expeditive C-3 vinylation of unprotected 3-iodoindazoles under microwave irradiation. Ten C-5 substituted 3-vinylindazole derivatives, nine of them novel, were synthesized through this method, which proceeds in moderate to excellent ...
Gonzalo Vera +3 more
doaj +1 more source
Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1
EcoEnergy, EarlyView.A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang +9 more
wiley +1 more source