Results 31 to 40 of about 4,056 (217)

The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

Molecules, 2012
The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave ...
Chiara Oliviero, Tecla Gasperi, Maria Antonietta Loreto, Antonella Migliorini   +3 more
doaj   +1 more source

A regioselective C7 bromination and C7 palladium-catalyzed Suzuki–Miyaura cross-coupling arylation of 4-substituted NH-free indazoles

, 2021
International audienceA direct and efficient regioselective C7-bromination of 4-substituted 1H-indazole has been achieved. Subsequently, a successful palladium-mediated Suzuki–Miyaura reaction of C7-bromo-4-substituted-1H-indazoles with boronic acids has
Boujdi, Khalid, Akssira, Mohamed, El Brahmi, Nabil, Dubreuil, Didier, Collet, Sylvain, Mathé-Allainmat, Monique, El Kazzouli, Saïd, Lebreton, Jacques, Nabil El Brahmi, Jérôme Graton, Sylvain Collet, Jacques Lebreton, Saïd El Kazzouli, Monique Mathé-Allainmat, Khalid Boujdi, Mohamed Akssira, Didier Dubreuil   +16 more
core   +1 more source

Preparation of Polyfunctional Indazoles and Heteroarylazo Compounds Using Highly Functionalized Zinc Reagents

, 2016
Readily available 2-chloromethylarylzinc reagents react with functionalized aryldiazonium tetrafluoroborates providing polyfunctional indazoles. Selective metalations of these 2-aryl-2H-indazoles afford new polycyclic aromatics.
Paul Knochel (1376235), Zhihua Peng (535169), Benjamin Haag (347756)   +2 more
core   +2 more sources

Rh(III)-catalyzed C–H acylmethylation of 2H-indazoles with sulfoxonium ylides

Journal of Saudi Chemical Society, 2020
An efficient Cp*Rh(III)-catalyzed direct acylmethylation of 2H-indazoles with sulfoxonium ylides has been realized under air atmosphere via chelation-assisted strategy.
Ya-Gai Wang, Jing Li, Xiao-Die Wang, Linlin Shi, Xinju Zhu, Xin-Qi Hao, Mao-Ping Song   +6 more
doaj   +1 more source

Anticonvulsant action of indazole

Epilepsy Research, 2013
Here we report that indazole is characterized as a potential anticonvulsant, inhibiting pentylenetetrazole-, electroshock- and strychnine-induced convulsions in mice (ED50's: 39.9, 43.2 and 82.4 mg/kg, respectively) but not bicuculline- and picrotoxin-induced convulsions.
Nobuko, Matsumura, Kazue, Kikuchi-Utsumi, Kentaro, Sakamaki, Masahiko, Watabe, Koji, Aoyama, Toshio, Nakaki   +5 more
openaire   +2 more sources

A Metal-Free Regioselective Multicomponent Approach for the Synthesis of Free Radical Scavenging Pyrimido-Fused Indazoles and Their Fluorescence Studies

Molecules, 2016
This study deals with a new and efficient metal-free regioselective synthesis of pyrimido-fused indazoles with nitrogen ring junction motifs. We have developed a metal-free domino type reaction between 3-aminoindazole, aryl aldehydes and aceotophenones ...
Jeyakannu Palaniraja, Selvaraj Mohana Roopan, G Mokesh Rayalu, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu   +4 more
doaj   +1 more source

Bromide-assisted chemoselective Heck reaction of 3-bromoindazoles under high-speed ball-milling conditions: synthesis of axitinib

Beilstein Journal of Organic Chemistry, 2018
A mechanically-activated chemoselective Heck coupling for the synthesis of 3-vinylindazoles has been developed with the aid of catalytic amounts of TBAB and NaBr as both dehalogenation restrainer and grinding auxiliary.
Jingbo Yu, Zikun Hong, Xinjie Yang, Yu Jiang, Zhijiang Jiang, Weike Su   +5 more
doaj   +1 more source

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity

Molecules, 2019
New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid.
Viviana Cuartas, María del Pilar Crespo, Eva-María Priego, Leentje Persoons, Dirk Daelemans, María-José Camarasa, Braulio Insuasty, María-Jesús Pérez-Pérez   +7 more
doaj   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie International Edition, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +1 more source

Syntheses of 1-Aryl-5-nitro-1H-indazoles and a General One-Pot Route to 1-Aryl-1H-indazoles

Molecules, 2018
An efficient route to substituted 1-aryl-1H-indazoles has been developed and optimized. The method involved the preparation of arylhydrazones from acetophenone or benzaldehyde substituted by fluorine at C2 and nitro at C5, followed by deprotonation and ...
Joel K. Annor-Gyamfi, Krishna Kumar Gnanasekaran, Richard A. Bunce   +2 more
doaj   +1 more source