Results 21 to 30 of about 4,056 (217)

Direct Arylations of 2H-Indazoles On Water

, 2016
The efficient palladium-catalyzed synthesis of a range of substituted 2H-Indazoles via C−H arylation is reported. Reactions are performed on water and provide a direct and mild route toward 2,3-diaryl indazoles of widespread biological ...
Michael F. Greaney (1299891), Stephan A. Ohnmacht (747230), Andrew J. Culshaw (2325298)   +2 more
core   +2 more sources

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles

Bulletin of Chemical Reaction Engineering & Catalysis, 2018
A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst.
Bashir Ahmad Dar, Syed Wasim Safvi, Masood Ahmad Rizvi   +2 more
doaj   +1 more source

19F‐NMR Diastereotopic Signals in Two N-CHF2 Derivatives of (4S,7R)-7,8,8-Trimethyl-4,5,6,7-tetrahydro-4,7-methano-2H-indazole

Molecules, 2017
In this paper, we report the anisochrony of the fluorine atoms of a CHF2 group when linked to a pyrazole ring. The pyrazole is part of (4S,7R)-7,8,8-trimethyl-4,5,6,7-tetrahydro-4,7-methano-2H-indazole also known as (4S,7R)-campho[2,3-c]pyrazole, which ...
Diana García-Pérez, Concepción López, Rosa M. Claramunt, Ibon Alkorta, José Elguero   +4 more
doaj   +1 more source

Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation

Health Technology Assessment, 2018
Background: Several therapies have recently been approved for use in the NHS for pretreated advanced or metastatic renal cell carcinoma (amRCC), but there is a lack of comparative evidence to guide decisions between them.
Steve J Edwards, Victoria Wakefield, Peter Cain, Charlotta Karner, Kayleigh Kew, Mariana Bacelar, Natalie Masento, Fatima Salih   +7 more
doaj   +1 more source

Development of a Continuous Photochemical Benzyne-Forming Process

SynOpen, 2021
A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm.
Cormac Bracken, Andrei S. Batsanov, Marcus Baumann   +2 more
doaj   +1 more source

LiO^tBu-Promoted Intramolecular 1,3-Dipolar Cycloaddition of the 2′-Alkynyl-biaryl-2-aldehyde N-Tosylhydrazones Approach to 3-Substituted 1H-Dibenzo[e,g]indazoles

Molecules, 2023
A two-step, one-pot synthesis of 3-substituted 1H-dibenzo[e,g]indazoles in good to high yields via a LiOtBu-promoted intramolecular 1,3-dipolar cyclization of 2′-alkynyl-biaryl-2-aldehyde N-tosylhydrazones was developed.
Jiaying Lv, Ruimao Hua
doaj   +1 more source

Indazoles: Regioselective Protection and Subsequent Amine Coupling Reactions

, 2016
Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodynamic conditions lead to regioselective protection at N-1.
David J. Slade (1522354), Nicholas F. Pelz (1352286), Paul S. Watson (2354788), John W. Lampe (2354785), Wanda Bodnar (801666)   +4 more
core   +2 more sources

The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole

Crystals, 2012
Two novel indazole derivatives protected with p-methoxybenzyl group were synthesized and characterized. The crystal and molecular structure of 2-(4-methoxybenzyl)-4-nitro-2H-indazole as one out of the two regioisomers is reported.
Constantin Mamat, Martin Köckerling, Kristin Ebert   +2 more
doaj   +1 more source

Pd(PPh₃)₄ Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Applied Sciences, 2020
A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches.
Jagan Mohana Rao Saketi, S. N. Murthy Boddapati, Raghuram M., Syed Farooq Adil, Mohammed Rafi Shaik, Osamah Alduhaish, Mohammed Rafiq H. Siddiqui, Hari Babu Bollikolla   +7 more
doaj   +1 more source

Efficient and Regioselective Synthesis of 2-Alkyl-2H-indazoles

, 2016
An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is ...
Mui Cheung (1523842), Jeffrey A. Stafford (2235520), Amogh Boloor (2425156)   +2 more
core   +1 more source