Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis [PDF]
, 2019 C3-substituted 1H-indazoles are useful and important substructures in many pharmaceuticals. Methods for direct C3- functionalization of indazoles are relatively rare, compared to reactions developed for the more nucleophilic N1 and N2 positions.
Ilia, Kevlishvili +4 more
core +3 more sources
Synthesis of 1H‑Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
ACS Omega, 2021 We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry.
Areum Park +3 more
doaj +2 more sources
Indazole: Photoleitfähigkeit und Oxidationspotentiale
CHIMIA, 1988 In sensitized electrophotographic layers, excellent charge transport properties are exhibited by 2-(p-aminophenyl)indazoles (1). Corresponding 2-aminoindazoles (2) are ineffective.
Bernhard Albert +2 more
doaj +1 more source
Photopromoted Free Radical Silylation of 2‑Aryl‑2H‑indazoles with Silanes
, 2023 Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles with good substrate scopes.
Luping Zheng (389782) +6 more
core +2 more sources
“On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole
Molecules, 2020 The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3 ...
Khadija Gambouz +7 more
doaj +1 more source
Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles
Frontiers in Chemistry, 2022 We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and ...
Chunhua Ma +7 more
doaj +1 more source
Synthesis of Novel N1 and N2 Indazole Derivatives
E-Journal of Chemistry, 2012 The alkylation of 5-cyano indazoles 2 in the presence of readily available imidizolium salts (ionic liquids) (Bmim)BF4 as phase transfer catalyst were performed to afford the regio isomers N1-and N2-(substituted alkyl)-5-cyano indazoles. The N1-alkylated
Prasanna Bethanamudi +4 more
doaj +1 more source
One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
Molecules, 2011 A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an ...
Antonio J. Lepore, Gary W. Breton
doaj +1 more source
Hg(II) Complexes Constructed from Indazole Ligands as New Heterogeneous Catalyst for the Biginelli/Transesterification Reaction: Synthesis and Quantum-Chemical Investigations [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 The present work deals with the synthesis, spectral characterization, DFT calculations, and catalytic activity of the new Hg(II) complexes derived from indazole ligands. The o-amino-ketones were obtained from the reduction of 6H-isoxazolo[4,3-e]indazoles
Elaheh Alikhani +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani +7 more
wiley +2 more sources