Results 1 to 10 of about 4,056 (217)

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

Molecules, 2016
A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl ...
Tsung-Hsun Chuang
exaly   +4 more sources

Synthesis of CF₃-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF₃-Imidoyl Sulfoxonium Ylides [PDF]

Molecules
An efficient Rh(III)-catalyzed C-H activation of azobenzenes and subsequent [4+1] cascade annulation with CF3-imidoyl sulfoxonium ylides was developed, yielding diverse CF3-indazoles.
Yilong Shang, Chen Li, Guiqiu Wang, Guiwei Yao, Hongliang Wu, Xun Chen, Ruirui Zhai   +6 more
doaj   +3 more sources

Nitroreductase-triggered indazole formation [PDF]

Nature Communications
Biocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen, Lisa Medema, Elizaveta Chernyshova, Alejandro Prats Luján, Gerrit J. Poelarends, Sandy Schmidt   +5 more
doaj   +2 more sources

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds [PDF]

Molecules
Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science.
Catarina M. Correia, Artur M. S. Silva, Vera L. M. Silva   +2 more
doaj   +2 more sources

Phototransposition of Indazoles to Benzimidazoles: Tautomer-Dependent Reactivity, Wavelength Dependence, and Continuous Flow Studies [PDF]

Angewandte Chemie - International Edition
Charles S Yeung, Richmond Sarpong, Christopher Barner-Kowollik   +2 more
exaly   +2 more sources

Synthesis of N-phenyl- and N-thiazolyl-1H-indazoles by copper-catalyzed intramolecular N-arylation of ortho-chlorinated arylhydrazones

Beilstein Journal of Organic Chemistry, 2022
The broad application of 1H-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular N-arylation of in situ-generated or isolated o ...
Yara Cristina Marchioro Barbosa, Guilherme Caneppele Paveglio, Claudio Martin Pereira de Pereira, Sidnei Moura, Cristiane Storck Schwalm, Gleison Antonio Casagrande, Lucas Pizzuti   +6 more
doaj   +1 more source

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

Beilstein Journal of Organic Chemistry, 2021
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient ...
Ryan M. Alam, John J. Keating
doaj   +1 more source

N-Difluoromethylindazoles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To study the possibility of the N-difluoromethylation and separation of 1-difluoromethyl and 2-difluoromethyl isomers of C-substituted indazoles, as well as some possibilities of functionalization of such molecules. Results and discussion.
Kirill I. Petko, Andrey A. Filatov
doaj   +1 more source

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions [PDF]

Royal Society Open Science, 2018
The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo ...
Scott H. Henderson, Ryan A. West, Simon E. Ward, Mark A. Honey   +3 more
doaj   +1 more source

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

Molecules, 2022
Designing new synthetic strategies for indazoles is a prominent topic in contemporary research. The transition-metal-catalyzed C–H activation/annulation sequence has arisen as a favorable tool to construct functionalized indazole derivatives with ...
Pezhman Shiri, Atefeh Roosta, Wim Dehaen, Ali Mohammad Amani   +3 more
doaj   +1 more source