Results 51 to 60 of about 4,056 (217)

A general synthesis of diversely substituted indazoles and hetero-aromatic derivatives from o-halo-(het)arylaldehydes or -phenones

, 2014
International audienceA set of variously substituted indazoles and hetero-aromatic derivatives were synthesized from o-halo-(het)arylaldehydes using a palladium catalyzed amination followed by cyclization.
Thibault Ferrary, Silvia Stiebing, Collot, Valérie, Stiebing, Silvia, Frederic Fabis, Fabis, Frédéric, Dubost, Emmanuelle, Cailly, Thomas, Thomas Cailly, Valerie Collot, Ferrary, Thibault, Emmanuelle Dubost   +11 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Synthesis and Crystallographic Characterisation of Pyridyl- and Indoleninyl-Substituted Pyrimido[1,2-b]Indazoles

Crystals, 2022
Pyridyl- and indoleninyl-substituted pyrimido[1,2-b]indazole were synthesised in good to high yields from the condensation reaction of 1,3-dialdehydes with 3-aminoindazoles. The structural features of the compounds were determined by NMR (1H, 13C and 19F)
Abdul Qaiyum Ramle, Sang Loon Tan, Edward R. T. Tiekink   +2 more
doaj   +1 more source

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

Synthesis of 3-Aryl-1H-Indazoles and Their Effects on Plant Growth

, 2013
Indazoles are valuable because of their biological activities. A series of 3-aryl-1H-indazoles have been synthesized by condensing bisulfite adduct of aromatic aldehydes with phenyl hydrazine in good yield.
Nagra, Saeed Ahmad, Chattha, Fauzia Anjum, Munawar, Munawar Ali, Khan, Misbahul Ain, Ashraf, Mohammad, Kosur, Samina   +5 more
core   +1 more source

Cis–Trans Rotational Isomerism of Formic Acid, Sulfur, and Selenium Analogues and Their Dimers: Chemical Kinetics Under Interstellar Conditions

International Journal of Chemical Kinetics, Volume 58, Issue 12, Page 1136-1145, December 2026.
ABSTRACT We present chemical kinetic rate constants for the cis to trans isomerisation or rotamerization of monomeric seleno‐, thio‐, and formic acids and that of three of their dimeric species, based on variational transition state theory and multidimensional tunneling calculations in the gas‐phase, from 10 K to 300 K. These provide, firstly, reliable
Judith Wurmel, John M. Simmie
wiley   +1 more source

A Suitable Functionalization of Nitroindazoles with Triazolyl and Pyrazolyl Moieties via Cycloaddition Reactions

Molecules, 2019
The alkylation of a series of nitroindazole derivatives with 1,2-dibromoethane afforded the corresponding N-(2-bromoethyl)- and N-vinyl-nitro-1H-indazoles.
Mohammed Eddahmi, Nuno M. M. Moura, Latifa Bouissane, Ouafa Amiri, M. Amparo F. Faustino, José A. S. Cavaleiro, Ricardo F. Mendes, Filipe A. A. Paz, Maria G. P. M. S. Neves, El Mostapha Rakib   +9 more
doaj   +1 more source

A Tale of Two Heterocycles: How Oxygen and Sulfur Shape Divergent Kemp Reactivity

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
Like benzisoxazoles, benzisothiazoles also undergo Kemp elimination, with rates accelerated by aprotic polar solvents and electron‐withdrawing groups. Oxygen‐containing heterocycles exhibit more localized negative charges than sulfur analogs, resulting in a more pronounced catalytic response to these environmental factors. ABSTRACT The Kemp elimination
Ella R. Jennings, Hannah S. Todd, Emilie Perelman, Courtney B. Limehouse, Hunter J. Savage, Marcello Forconi   +5 more
wiley   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

, 2017
A new nickel-catalyzed cyclization of ortho-chlorobenzophenone hydrazones, to afford 3-aryl-1H-indazoles, is applied in a one-pot synthesis of 1,3-diaryl-1H-indazoles.
Mark Stradiotto, Christopher M. Lavoie, Helio G. Bonacorso, Carson Wiethan, Jillian S. K. Clark, Andrey Borzenko   +5 more
core   +1 more source