Results 71 to 80 of about 4,056 (217)
Machine Learning for Synthetic Organic Chemistry: Methods, Applications, and Best Practices
Angewandte Chemie Novit, Volume 2, Issue 3, September 2026.Artificial intelligence (AI) and machine learning (ML) are increasingly reshaping experimental chemistry. This review maps the challenges of synthetic organic chemistry to modern digital tools that can help address them. While focusing on the practical application of ML tools in real‐world laboratory settings, we outline prerequisites, emerging ...
Niklas Hölter +3 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Sixteen indazole–sulfonamide hybrids exhibit species‐dependent antibacterial activity against E. coli and S. aureus, with the lead compound displaying an eightfold lower MIC than sulfathiazole against E. coli. Molecular docking against wild‐type and Sul1‐resistant dihydropteroate synthase identifies a candidate retaining binding affinity toward the ...
Romaisaa Boudza +8 more
wiley +1 more source
Synthesis of Indazoles via N–N Bond-Forming Oxidative Cyclization from 2‑Aminomethyl-phenylamines
Herein we report a method for the synthesis of indazoles from readily available 2-aminomethyl-phenylamines via N–N bond-forming oxidative cyclization. Inspired by indazole formation initially observed as a side product by N. Coskun et al.
Jale Karolyi-Oezguer (3346655) +6 more
core +1 more source
Molecules, 2006 A series of indazoles substituted at the N-1 and N-2 positions with ester-containing side chains -(CH2)nCO2R of different lengths (n = 0-6, 9, 10) are described.Nucleophilic substitution reactions on halo esters (X(CH2)nCO2R) by 1H-indazole inalkaline ...
Isabel Bento +5 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley +1 more source
A Method for the Regioselective Synthesis of 1-alkyl-1H-indazoles
, 2013 [[abstract]]A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described.
Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey
core
Molecules, 2017 Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma.
Yangyang Yao +11 more
doaj +1 more source
, 2016 The [3+2] cycloaddition of a variety of diazo compounds with o-(trimethylsilyl)aryl triflates in the presence of CsF or TBAF at room temperature provides a very direct, efficient approach to a wide range of potentially biologically and pharmaceutically ...
Feng Shi (305643) +4 more
core +2 more sources
Dimerisation, rhodium complex formation and rearrangements of N-heterocyclic carbenes of indazoles
Beilstein Journal of Organic Chemistry, 2014 Deprotonation of indazolium salts at low temperatures gives N-heterocyclic carbenes of indazoles (indazol-3-ylidenes) which can be trapped as rhodium complexes (X-ray analysis).
Zong Guan +4 more
doaj +1 more source
Flash Pyrolysis – Synthetic and Mechanistic Aspects
CHIMIA, 1977 Some examples of synthetically useful flash pyrolysis reactions are presented, and the reaction mechanisms are discussed. Cyanocyclopentadienes, -indenes, and -pyrroles are produced by pyrolysis of the appropriate triazoloarenes or isatins, or as the ...
Curt Wentrup
doaj +1 more source