Results 101 to 110 of about 5,024 (202)

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–H ...
Jonathan Elie, Johnny Vercouillie, Nicolas Arlicot, Lucas Lemaire, Rudy Bidault, Sylvie Bodard, Christel Hosselet, Jean-Bernard Deloye, Sylvie Chalon, Patrick Emond, Denis Guilloteau, Frédéric Buron, Sylvain Routier   +12 more
doaj   +1 more source

Synthesis and Characterization of Novel Indazole–Sulfonamide Compounds with Potential MAPK1 Inhibitory Activity for Cancer Treatment

Molbank
Indazoles are a very important group of nitrogen-containing heterocycles with a wide range of biological and medicinal applications. These properties make them highly attractive for drug development, particularly when combined with sulfonamides to ...
Nassima Saghdani, Abdelali Chihab, Nabil El Brahmi, Saïd El Kazzouli   +3 more
doaj   +1 more source

Interaction of Bioactive Pyrazolo[4,3-a]acridines with Human Serum Albumin [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
Several heterocyclic bioactive fluorescent 3-alkyl-3H-pyrazolo[4,3-a]acridin-11-carbonitriles were conveniently synthesized from the reaction of 1-alkyl-1H-indazoles with different aryl acetonitrile in basic methanol solution in good yields.
Fatemeh Khosravi, Mehdi Pordel, Abolghasem Davoodnia   +2 more
doaj  

New Syntheses of Indazole and 2-Substituted Indazoles. [PDF]

Acta Chemica Scandinavica, 1975
Jan M. Bakke, Kjell A. Skjervold, Birgitta Gotthammar   +2 more
openaire   +1 more source

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-CARBETHOXY-5-(3'-BROMOPHENYL)-3-ARYL-2-CYCLOHEXENONES AND 6-ARYL-4-(3'-BROMOPHENYL)-3-OXO-2,3A,4,5-TETRAHYDRO-2H-INDAZOLES [PDF]

Journal of Sciences, Islamic Republic of Iran, 2002
6-Carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-Aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by Micheal addition of ethyl acetoacetate, followed by internal Claisen condensation.
doaj  

Combined Gold and Photoredox Catalysis: Synthesis of 3-Alkenyl-2H-Indazoles from 2-Alkynylazobenzenes [PDF]

We disclose the intramolecular synthesis of 3- alkenyl-2H-indazoles from 2-alkynylazobenzenes, promoted by a dual catalysis using AuCl3 and a ruthenium photocatalyst under visible light irradiation.
Mañas Hernández, Clara, Merino Marcos, Estíbaliz   +1 more
core   +1 more source

Recent progress in ionic liquid-catalyzed multicomponent reactions: a green and sustainable approach to organic synthesis in line with the UN SDGs

Green Chemistry Letters and Reviews
Traditional synthetic methods frequently rely on hazardous reagents, consume significant energy, and generate considerable amounts of chemical waste, thereby posing serious environmental and safety concerns.
Jayanthi Barasarathi, Magdi E. A. Zaki, K. Venkatesan, P. Karthikeyan, Ling Shing Wong, Sobhi M. Gomha   +5 more
doaj   +1 more source

Synthesis, Characterization, In-silico and Biological Evaluation of Indazole Derivatives as Potential Anti-Inflammatory and Antimicrobial Agents

RGUHS Journal of Pharmaceutical Sciences
Introduction Indazoles also known as isoindazone or benzpyrazole are fused bicyclic heteroaromatic organic molecules with a wide range of biological activities.
Hanamant B Sannakki, Somashekhar Metri, Amit Mandave, Trupti A Hunnura, Pratik M, Vishal Babar, Mahesh AR   +6 more
doaj   +1 more source

Fluoração de 2H-Indazoles [PDF]

Boletim da Sociedade Portuguesa de Química, 2021
openaire   +1 more source

Rh(III)-Catalyzed Regioselective [4 + 2] Annulation of 2-Benzyl-2H-indazole-6-carboxylic Acids with Ynamides to Access Indazole-Fused Pyrans. [PDF]

J Org Chem
Hsieh HS, Liu KM, Chao CM, Barve IJ, Sun CM.   +4 more
europepmc   +1 more source