Results 111 to 120 of about 1,974,122 (287)

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

On the number of maximum independent sets of graphs [PDF]

open access: yesTransactions on Combinatorics, 2014
Let $G$ be a simple graph. An independent set is a set of pairwise non-adjacent vertices. The number of vertices in a maximum independent set of $G$ is denoted by $alpha(G)$. In this paper, we characterize graphs $G$ with $n$ vertices and with maximum
Tajedin Derikvand, Mohammad Reza Oboudi
doaj  

Treewidth versus clique number. II. Tree-independence number [PDF]

open access: green, 2021
Clément Dallard   +2 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Quest for A Characterization of Hom-Properties of Finite Character

open access: yesDiscussiones Mathematicae Graph Theory, 2016
A graph property is a set of (countable) graphs. A homomorphism from a graph G to a graph H is an edge-preserving map from the vertex set of G into the vertex set of H; if such a map exists, we write G → H.
Broere Izak   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

On k-prime graphs

open access: yesOpen Mathematics
In the context of a simple undirected graph GG, a kk-prime labeling refers to assigning distinct integers from the set {k,k+1,…,∣V(G)∣+k−1}\left\{k,k+1,\ldots ,| V\left(G)| +k-1\right\} to its vertices, such that adjacent vertices in GG are labeled with ...
Abughneim Omar A., Abughazaleh Baha’
doaj   +1 more source

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