Results 121 to 130 of about 9,781,779 (300)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Central bank independence and ageing [PDF]
We contrast the influence of demography and central bank independence on inflation. The recent demographic trends in developed countries are shown to weight more on inflation than central bank independence, while the contrary stands for the period from ...
Lagadec, Gaël +2 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Direct proofs of order independence [PDF]
We establish a generic result concerning order independence of a dominance relation on finite games. It allows us to draw conclusions about order independence of various dominance relations in a direct and simple way.dominance relations,order ...
Krzysztof R. Apt
core
Subgroup intersection graph of finite abelian groups [PDF]
Transactions on Combinatorics, 2012 Let G be a finite group with identity e. The subgroup intersection graph Gamma_SI (G) of G isa graph with vertex set G − e and two distinct vertices x and y are adjacent if and only if | i ∩ | | > 1.
T. Tamizh Chelvam, M. Sattanathan
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The degree of commitment to regulator independence: measurement and impact [PDF]
This study computes measures of the degree of independence in practice of telecommunications regulators for Latin American and Caribbean countries in a new data set for 23 countries between 1990 and 2004.
Miguel Angel Montoya, Francesc Trillas
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Do We Really Need Central Bank Independence? A Critical Re- examination [PDF]
In this survey, we critically review the argument for central bank independence (CBI). We argue CBI is neither necessary nor sufficient for reaching monetary stability.
Carsten Hefeker, Bernd Hayo
core