Results 291 to 300 of about 16,633,437 (341)

Neddylation-Independent Activities of MLN4924

Advances in Experimental Medicine and Biology, 2020
MLN4924, also known as pevonedistat, is a highly selective small-molecule inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8)-activating enzyme (NAE) to block the entire neddylation modification cascade, leading to inactivation of cullin-RING ligases (CRLs), since activation of CRLs requires cullin neddylation.
Hongmei, Mao, Yi, Sun
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Synergy among Seemingly Independent Activities*

Contemporary Accounting Research, 2002
Abstract“Synergy” implies that the value of activities undertaken jointly is greater than the sum of the values of the individual activities. Reasons cited for synergy include economies of scale, benefits due to vertical integration, and efficiency gains from shared inputs and skills.
Anil Arya
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Event Trace Independence of active behavior

Information Processing Letters, 2005
We present the Event Trace Independence (ETI), a novel property of active rules exhibiting a behavior independent of the specific event sequence that had caused a state transition. When employed in a distributed setting, this property supersedes the classical property of confluence, which is not sufficient herein.
Angela Bonifati, Stefano Ceri, Stefano Paraboschi   +2 more
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Ligand-independent activation of steroid receptors

Domestic Animal Endocrinology, 2002
In several transformed cell lines, the growth factors IGF-I and epidermal growth factor (EGF) activate second messenger systems that cause the phosphorylation of the estrogen receptor (ER). One kinase catalysing receptor phosphorylation is mitogen activated protein (MAP) kinase, and the result of phosphorylation is an increase in receptor ...
A P F, Flint, E L, Sheldrick, P A, Fisher   +2 more
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Independent activity of catalase haematins

Journal of Theoretical Biology, 1970
Abstract The peroxidatic mechanism for the catalytic reaction and for peroxidation has been extended from haematin basis to include the catalase molecule as a whole. It has been shown that interaction among single haematin units does not affect the form of the rate equations for the catalatic reaction.
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Two independent indices of activation

Electroencephalography and Clinical Neurophysiology, 1960
Abstract Two indices of “activation”, Wenger's estimate of relative autonomic balance (Ā) and per cent-time alpha, were obtained from 42 male undergraduate subjects. No correlation was found between them. The indices were judged to measure independent functions, and it was concluded that a general “activation” theory of emotions is not yet justified.
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On the demand for independent and active audit committees

Journal of Corporate Finance, 2000
Abstract We extend the literature on director independence and the role of the board by focusing on the importance of audit committees in the contracting process. We find that the demand for independent and active audit committees is positively related to the demand for accounting certification.
Daniel N. Deli, Stuart L. Gillan
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Acetylcholinesterase activation of peritoneal macrophages is independent of catalytic activity

Cellular and Molecular Neurobiology, 1994
1. In diverse tissues, acetylcholinesterase appears to play a critical role in the functional state of cells completely dependent of cholinergic transmission. However, very little is known about the mechanisms and actual molecular structures mediating the fundamental interactions between this protein and the cellular membrane. 2.
A, Klegeris, T C, Budd, S A, Greenfield
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Alloantigen-Activated CML Suppression Independent of Cytotoxic Activity

The Journal of Immunology, 1979
Abstract The generation of T cell-mediated lympholysis (CML) in murine mixed lymphocyte cultures (MLC) can be impeded if allogeneic responding and stimulating cells are incubated in the presence of lymphocytes that have been activated by prior exposure to alloantigens (1–6).
C G, Orosz, F H, Bach
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